ABSTRACT
Abstract Introduction Sickle cell disease is an autosomal recessive genetic disease caused by a single point mutation in the β-globin chain of the hemoglobin. It has been recognized by the World Health Organization as a public health priority since 2006. Methods The Scopus database was used in this study with the search descriptors: "sickle cell" and "sickle cell disease". We applied common bibliometric indicators to evaluate the trend in scientific literature in sickle cell disease research. Results We retrieved a total of 19,921 pieces of scientific literature in the repertoire from 1997 to 2017. The Price law was fulfilled in the trend of production of scientific literature on SCD as the growth of scientific literature was more exponential (r = 0.9751; r2 = 0.9509) than linear (r = 0.9721; r2 = 0.9449). We observed a duplication time of 4.52 years. The Bradford core was made up of 69 journals with Blood at the top, publishing the greatest number of articles. The most productive institutions were mostly United States agencies and hospitals. The United States was the most productive country. The National Institute of Health was the most productive institution and also had the highest number of citations. Vichinsky E was the most productive author, while the most cited article was published by Circulation. Conclusion The growth of scientific literature in Sickle cell disease was found to be high. However, the exponential growth trend shows a "yet-to-be-explored" area of research. This study will be useful for physicians, researchers, research funders and policy-cum-decision makers.
Subject(s)
Bibliometrics , Anemia, Sickle CellSubject(s)
Humans , Adult , Middle Aged , Psychiatry , Rehabilitation , Costa Rica , Quality of Health CareABSTRACT
Se analiza la omisión de la inscripción de defunciones neonatales en 74 nacidos vivos en la maternidad del hospital de Chillán, con peso inferior a 1.500 g al nacer, entre el 1§ de enero y 31 de diciembre de 1986. Se adoptan las definiciones recomendadas por la OMS para defunción fetal, neonatal y nacido vivo. El porcentaje de omisión alcanza a 30,6%, es mayor en las defunciones de la primera hora de vida (75%) y en los neonatos con peso menor de 750 g (58%). No existen diferencias significativas en la inscripción de la defunción neonatal con respecto a la edad, estado civil, nivel de instrucción de la madre y orden de paridad del producto, pero sí en el promedio de peso del nacimiento: 731 g en el grupo con inscripción de la defunción. El factor determinante en la no inscripción de la defunción neonatal parece ser el inadecuado registro de los hechos vitales y no la deficiente aplicación de las definiciones recomendadas por la Organización Mundial de la Salud. Las tasas de mortalidad según peso, corregidas de acuerdo a la omisión de nacimientos y defunciones, no difiere mayormente de otras series nacionales