ABSTRACT
Tamoxifen is widely used for the treatment of breast cancer and currently proposed for preventive strategies. However. there is evidence that tamoxifen may affect other hormone sensitive organs, such as uterus and ovary. It has been documented that tamoxifen treatment is associated with development of endometrial polyp, endometrial hyperplasia, ovarian and endometrial cancer. Uterine malignant mixed mullerian tumor is a neoplasm which apparently arises from undifferentiated mullerian stroma and is composed of a mixture of malignant epithelial and stromal component. We report a case of malignant mixed mullerian tumor of uterus which was developed in a patient treated with tamoxifen for 5 years following a modified radical mastectomy due to breast cancer.
Subject(s)
Female , Humans , Breast Neoplasms , Breast , Endometrial Hyperplasia , Endometrial Neoplasms , Mastectomy, Modified Radical , Ovary , Polyps , Tamoxifen , UterusABSTRACT
OBJECTIVE: The aim of this study was to examine whether polymorphic variation in GSTs confers susceptibility to Endometriosis in Korean populations. METHODS: The GSTM1, GSTT1, and GSTP1 genotypes were determined in 124 patients with Endometriosis (stage 3, 4) and 155 healthy control subjects at Ewha woman's university Mok-dong hospital from 1996 to 2003. RESULTS: The homozygous wild allele in GSTP1 gene was most common genotypes both Endometriosis and healthy control groups (69.4% vs. 64.5%). Neither the heterozygous nor homozygous mutant allele in GSTP1 gene differed in frequency between the two groups (30.6% vs 35.5%). When null mutations in GSTM1, GSTT1 were combined with GSTP1 polymorphism, there was no evidence of increase in the risk of endometriosis, as the number of high risk alleles of the GST family increased. CONCLUSION: Our findings suggest that GSTP1 genetic polymorphism may not be associated with development of Endometriosis in Korean populations. There is no evidence of a trend in increasing risk with the number of putative high risk alleles of the GST family carried.
Subject(s)
Female , Humans , Alleles , Endometriosis , Genotype , Polymorphism, GeneticABSTRACT
OBJECTIVE: To determine the frequency and degree on change in mammographic densities, and calcification in the breast tissue, during different types of hormone replacement therapy and to evaluate the factors that play a role on the breast cancer. METHOD: A retrospective review of 268 cases menopausal women for HRT group and 52 cases menopausal women for unmatched control group. Mammographic evaluations for the distribution of breast densities and calcification, new solid mass and cyst in four different type of HRT were performed each every year during 5 years. The significant increase of breast densities and calcifications and new formation of neoplasm were taken with breast sonogram. 10 cases were biopsied for the confirmation of maliganancy. RESULT: Compared with the conrol groups, the hormone user group have a significant increase in the breast densitiy for 5 years (p0.05). Among 10 cases in suspicious malignancy, 9 cases were confirmed to the malignancy by biopsy. CONCLUSION: The results of this study revealed that not only progesterone combined HRT but also estrogen only HRT significantly increased mammographic density. There is no relationship on the calcification and HRT in this study. The annual checking of mammography is necessary to HRT.
Subject(s)
Female , Humans , Biopsy , Breast Neoplasms , Breast , Estrogens , Hormone Replacement Therapy , Mammography , Progesterone , Retrospective StudiesABSTRACT
OBJECTIVE: To determine the frequency and degree on change in mammographic densities, and calcification in the breast tissue, during different types of hormone replacement therapy and to evaluate the factors that play a role on the breast cancer. METHOD: A retrospective review of 268 cases menopausal women for HRT group and 52 cases menopausal women for unmatched control group. Mammographic evaluations for the distribution of breast densities and calcification, new solid mass and cyst in four different type of HRT were performed each every year during 5 years. The significant increase of breast densities and calcifications and new formation of neoplasm were taken with breast sonogram. 10 cases were biopsied for the confirmation of maliganancy. RESULT: Compared with the conrol groups, the hormone user group have a significant increase in the breast densitiy for 5 years (p0.05). Among 10 cases in suspicious malignancy, 9 cases were confirmed to the malignancy by biopsy. CONCLUSION: The results of this study revealed that not only progesterone combined HRT but also estrogen only HRT significantly increased mammographic density. There is no relationship on the calcification and HRT in this study. The annual checking of mammography is necessary to HRT.
Subject(s)
Female , Humans , Biopsy , Breast Neoplasms , Breast , Estrogens , Hormone Replacement Therapy , Mammography , Progesterone , Retrospective StudiesABSTRACT
Choriocarcinoma is a malignant tumor arising from chorionic villi following normal or abnormal gestation. It rarely originates in the extragonadal region such as retroperitoneum and mediastinum. In these extragonadal choriocarcinomas, primary gastric choriocarcinoma is extremely rare. A 37-year old woman with primary choriocarcinoma of the stomach presented with amenorrhea and anemia. Serum level of beta-hCG was moderately elevated. There was gastric choriocarcinoma with histologic pattern of adenocarcinoma. We wish to report the extremely rare finding of a choriocarcinoma occurring as a primary gastric neoplasm with gynecologic symptom.