ABSTRACT
The objective of this study was to detect the presence of local edema and hemorrhage caused by Crotalus durissus terrificus envenoming using magnetic resonance imaging (MRI). Six patients bitten by Crotalus durissus terrificus snakes were treated at the Emergency Unit and Tropical Diseases Unit of Botucatu School of Medicine, UNESP, Säo Paulo State, Brazil. After receiving specific serotherapy, the patients were submitted to MR of the bite site. Post contrast T1 and T2 spin-echo MRI were obtained revealing the following lesions: edema associated with hemorrhage in subcutaneous and muscular tissue (n=3), edema in subcutaneous tissue (n=2), and perimuscular hemorrhage (n=1). In this study, MR demonstrated a local effect of Crotalus durissus terrificus envenoming in inducing edema and hemorrhage, mainly in muscular tissues and perimuscular areas. These results indicate that Crotalus durissus terrificus venom cause a local muscular tissue damage in human envenoming represented by edema and hemorrhage.
Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Brazil , Crotalid Venoms , Skin , Snake Bites , Edema , Hemorrhage , Immunization, Passive , Magnetic Resonance ImagingABSTRACT
The objective of this clinical study was to evaluate local tissue damage caused by Bothrops sp envenoming in relation to lesion type and damaged tissues using magnetic resonance imaging (MRI). Fifteen patients bitten by Bothrops snakes were treated at the Emergency Unit of the Tropical Diseases Unit at the University Hospital, Botucatu School of Medicine, UNESP, Säo Paulo State, Brazil. After receiving specific serotherapy, the patients were submitted to MR of the bite site. T1 spin-echo MRI were obtained revealing the following lesions: edema (n=9), edema associated with hemorrhage (n=5), and hemorrhage (n=1). Perimuscular areas (n=6) and subcutaneous tissues (n=5) were the most affected, followed by muscular tissues (n=4). It is important to mention that MRI did not show myonecrosis of the bite site, a widely reported finding in anatomical and histopathological experimental studies.
Subject(s)
Humans , Male , Female , Child , Aged , Adolescent , Adult , Middle Aged , Bothrops , Brazil , Magnetic Resonance Imaging/classification , Skin , Snake Bites , Crotalid Venoms/adverse effects , Soft Tissue Injuries/physiopathologyABSTRACT
Apresenta-se um paciente do sexo masculino, de 11 meses e 6 dias, que apresentava adenopatia cervical, axilar e inguinal há 1 semana e diminuiçäo de atividade, palidez, vômitos pós-alimentares e dificuldade respiratória há 3 dias. Antecedentes familiares: baixa condiçäo sócio-econômica e mäe com Tbc, e tratamento irregular durante esta gestaçäo. O paciente nasceu com desnutriçäo intra-uterina, apresentava retardo de desenvolvimento deformidade torácica. Pelo exame clínico e radiológico tratava-se de paciente com tuberculose pulmonar e vertebral. Foi iniciado esquema tríplice, imobilizaçäo no leito e posteriormente colete de gesso. Após 5 meses de tratamento a criança passou a sentar sozinha e trocar passos e com 2 anos estava andando e correndo, apesar do quadro radiológico de coluna ficar inalterado
Subject(s)
Infant , Humans , Male , Tuberculosis, Spinal/diagnosis , Tuberculosis, SpinalABSTRACT
Foram tratados 12 doentes atendidos na Disciplina de Molestias Infecciosas e Parasitarias da Faculdade de Medicina de Botucatu com diagnostico etiologico de paracoccidioidomicose que apresentavam lesoes organicas multiplas e evolucao prolongada.O tratamento foi realizado por 18 meses, com o Ketoconazol, pela via oral, nas doses diarias de 400 mg no primeiro mes e de 200 mg nos meses seguintes. Todos os doentes foram acompanhados durante o tratamento e, em media 4 meses e meio apos o mesmo, clinica, radiologica e sorologicamente pelas reacoes de imunofluorescencia indireta, precipitinas e imunodifusao em gel.A competencia imunitaria foi avaliada em todos os doentes antes do tratamento e repetida em quatro, no final do mesmo. Os resultados mostraram que houve recaida em 5 doentes. A droga foi bem tolerada e a imunodifusao em gel e a hemossedimentacao foram as provas que mostraram maior paralelismo com a evolucao clinica