ABSTRACT
Vitamin D receptors are located in body tissues and cells. In variousphysiological processes of the body the primary circulating formof vitamin D, 25-hydroxyvitamin D, will become the active form,1,25-dihydroxyvitamin D, through many enzymatic. Although differentfunctions of vitamin D has been identified, reducing the possibility ofseveral chronic diseases, including common cancers, autoimmune,infectious, and cardiovascular diseases is proposed as the major role ofthis component. According to various experimental and clinical studies,vitamin D affects the immune system activity. In this review we studythe possible effects of vitamin D on sepsis. The purpose of this review isto evaluate and summarize the role of vitamin D in the immune system,with particular focus on infections and sepsis. We studied different areasrelated to vitamin D in the literature review including its roles sepsis andinfection incidence, as well as seasonal and racial variation in sepsis. Basedon evidence, vitamin D positively affects the immune system, so it mightact as a therapeutic strategy. Despite several experimental studies whichdemonstrated the beneficial effects of vitamin D on improved functioningof the immune system, its association with prevention or management ofinfections and sepsis is not revealed through clinical investigations