ABSTRACT
Background: asymptomatic bacteriuria [ASB] during pregnancy is the primary cause of acute pyelonephritis, preterm labor, low birth weight fetus, etc., if left untreated. Adequate and early treatment reduces the prevalence of these obstetric complications
Objectives: this study aimed to determine the prevalence of ASB during pregnancy and determine the association between asymptomatic bacteriuria and spontaneous preterm birth
Patients Methods: this was a case control study of 120 preterm pregnancies and 40 term pregnancies among those attending El-Galaa Teaching Hospital, Obstetric Emergency Unit to evaluate the incidence of ASB and determine the association between asymptomatic bacteriuria and spontaneous preterm birth from March 2016 to March2017.Urine analysis and culture with antibiotic sensitivity were performed
Results: out of the 160 patients studied, ASB was observed in 7 patients [6 cases in preterm group [5%] and 1 case in full term group [2.5%] with no significant difference between the two groups [p-value. 0.05], the incidence of ASB in preterm labor was quite lower 5%. E. coli was the most common pathogen [55.14%] followed by proteus 28.57 followed by klebsiella [14.28%]
Conclusion: all pregnant women should be screened by urine culture to detect asymptomatic bacteriuria at their first visit to prevent overt urinary tract infections [UTI] and other complications in both mother and fetus
ABSTRACT
Objective: This study aimed to evaluate the efficacy of short and extended long course of letrozole therapy for ovulation induction in clomiphene resistant women with polycystic ovary syndrome
Patients: One hundred infertile women were selected from the patients attending the outpatient clinic of Manshiet El-Bakry general hospital. All patients were diagnosed as having anovulation due to polycystic ovary syndrome [PCOS]. Interventions: Patients were randomly allocated to treatment with either long letrozole group took 2.5 mg of letrozole daily starting day 1 of spontaneous or progesterone inducing menstrual bleeding for 10 days [50 patients, up to 3 cycles] or short letrozole group took 5 mg of letrozole daily starting day 1 of spontaneous or progesterone inducing menstrual bleeding for 5 days [50 patients, up to 3 cycles]
Results: The number of ovulating patients was greater in the long letrozole group [74% vs. 56%], but without statistical differences. The total number of follicles during stimulation was insignificantly greater in the long letrozole group [8.2 vs. 8.17]. The numbers of follicles =18 mm were significantly greater in the long letrozole group. Pregnancy occurred in 7 in the short group [14%] and 12 of [24%] in the long letrozole group, and the difference was statistically insignificant
Conclusion: The long letrozole protocol [10 days] can produce more mature follicles and subsequently more pregnancies than the short letrozole therapy [5 days]