ABSTRACT
There are controversies about the concentration of thyroid hormones in preeclamptic patients and its clinical significance. To study the thyroid hormones levels in severe preeclamptic This study included 63 pregnant women [31 with severe preeclampsia and 32 healthy normotensive controls]. Patients were stratified according to gestational age. Free T3 [triiodothyronine] free T4 [thyroxin] and TSH [thyroid stimulating hormone] were measured using radioimmunoassay. Mean TSH is significantly increased in preeclamptic patients as compared to control subjects' while FT4, FT3 were comparable in both groups. TSH levels were not correlated to gestational age or severity of preeclampsia. Mean serum TSH levels were significantly increased without concomitant changes in FT4, FT3 in severe preeclampsia compared to normal pregnancy and this hormonal change was not related to gestational age or degree of severity of preeclampsia. The values of those findings are not clear. However, abnormal TSH titer might be associated with a risk for occurrence of preeclampsia, so studying TSH levels in high risk women form early pregnancy might be of value in the prediction of preeclampsia