Genomic Analysis for Preventing Complications due to Proton Pump Inhibitor and Warfarin Combination Therapy after Open-Heart Surgery / 日本心臓血管外科学会雑誌

<b>Objective</b> : Prevention of gastrointestinal bleeding is imperative in perioperative management of open-heart surgery. Although both proton pump inhibitors (PPIs) and Warfarin are often prescribed to patients following cardiac surgery, the US FDA warns that PPIs increase the international normalized ratio (INR) when used concomitantly with Warfarin, by being metabolized by cytochrome P-450 (CYP) 2C19. We assessed whether this drug interaction depends on the genotype of CYP2C19 (Extensive Metabolizer, EM ; Intermediate Metabolizer, IM ; Poor Metabolizer, PM) or the type of PPI. <b>Methods and Results</b> : In this observational prospective study, the CYP2C9, CYP2C19, and VKORC1 genotypes of 78 patients were analyzed. After excluding cases with ^*1/^*3 of the CYP2C9 genotype and those with C/T of the VKORC1 genotype, 60 patients were assigned to Warfarin+Rabeprazole (RB group, 30 cases) or Warfarin+Lansoprazole (LP group, 30 cases). Warfarin was started with an initial dose of 3 mg, and INR values were measured on days 4, 8, 14, 28, and 56. There was no significant difference in median Warfarin dose between the LP group (2.5 mg/day) and RB group (3.0 mg/day), (<i>p</i>=0.88). The time in the therapeutic range (TTR) (Rosendaal) was significantly higher in the RB group (83.7%) than in the LP group (49.4%), and the time in the over range was significantly higher in the LP group (41.9%) than in the RB group (0.0%). In the LP group, TTR values were higher in CYP2C19 Extensive Metabolizers (EMs) than in Intermediate Metabolizers (IMs) and Poor Metabolizers (PMs), but there was no statistically significant difference between them. Conversely, in the RB group, there was no difference in the values of any CYP2C19 genotype. A multivariate analysis showed that high age and low TTR were risk factors for bleeding. <b>Conclusion</b> : We consider it possible that lower TTR values in the LP group were affected by the CYP2C19 genotype. In an aging society, Rabeprazole is safer and more effective as a proton pump inhibitor after open-heart surgery.

Study of Event Database for Improving Efficiency and Reliability of Data Input to JACVSD / 日本心臓血管外科学会雑誌

The Japanese adult cardiovascular database (JACVSD) contains details of all adult cardiovascular surgeries performed in Japan. This database has the potential to make data from all of Japan available to the world in the future. However, it is time consuming to enter several items from an individual terminal for all cases ; adding further pressure to already busy routine work. In our facilities, an original system using Filemaker Pro has been developed and used since 2004. This system has various functions integrated into it, and currently, the input system of JACVSD has been added. As a result, it becomes possible to automatically enter more than half the data of JACVSD, and excellent results can be reported. Intellectual property rights have been owed by Nihon University since 2007.

A Case of Postinfarction Left Ventricular Free Wall Rupture in an Elderly Patient / 日本心臓血管外科学会雑誌

An 85-year-old man was admitted complaining of chest pain. The ECG showed ST depression in leads II, III, _aV_F, V₃-V₆ and Q wave in leads I, _aV_L with elevation in ST segments. An emergency coronary angiography revealed 75% stenosis in the left main trunk, 75-90% stenosis in the left anterior descending artery, total occlusion in the acute marginal branch, 75% stenosis in the left circumflex artery, and 75% stenosis in the right coronary artery. He was treated medically, because he was old and his hemodynamics were stable. About 39h later, he lost consciousness suddenly and was shown to have cardiogenic shock. Echocardiogram revealed pericardial effusion. Percutaneous drainage was performed, resulting in improved blood pressure and level of consciousness. He was transferred to Okaya Enrei Hospital and received emergency surgery for subacute LVFWR. A sutureless repair and coronary bypass was performed under cardiopulmonary bypass and cardiac arrest. He experienced no major complication and was discharged 40 days after surgery. It is concluded that the sutureless technique allowed for a shorter operation time and concomitant coronary bypass successfully prevented pseudoaneurysm and improved cardiac function. A higher quality operation is possible by using a combination of on-pump, cardiac arrest, coronary bypass and left ventricle repair with the sutureless technique in such cases in which treatment is needed for cardiac arrest as in the above example. This method contributed to an improved prognosis.

Abdominal Aortic Aneurysm Accompanied by Aortic Dissection / 日本心臓血管外科学会雑誌

Three cases of aortic dissection involving abdominal aortic aneurysms are reported. Two of the 3 cases died from intestinal necrosis. In one of them, the abdominal aortic aneurysm ruptured following aortic dissection. Fenestration was not performed at the proximal anastomosis in the operation, and it is thought that this resulted in occurrence of intestinal necrosis due to superior mesenteric artery obstruction. In the other non-survivor, aortic fenestration and graft replacement were performed. However, he died from descending-sigmoid colon necrosis due to internal iliac artery obstruction. An autopsy demonstrated no problem that with the graft anastomosis. The successful case of aortic fenestration and graft replacement had no postoperative complications. Since the aortic wall is fragile in acute aortic dissection, it is advisable that operation be conducted 1 month after the onset except in cases of aortic rupture and malperfusion syndrome. Fenestration, which is usually safe in chronic dissection, should be performed and it is desirable to fenestrate the aortic wall if possible even in acute dissection.

Treatment for Acute Type A Aortic Dissection in the Elderly / 日本心臓血管外科学会雑誌

Patients with Stanford A acute aortic dissection who were treated within 48h of onset in our institution between January 1, 1999 to December 31, 2001 were divided into those younger than 70 years and those 70 years or older to compare the results of surgical and conservative therapies and the cause of death. The total number of patients was 74, the age was 33 to 88 years (66.5±11.9 years), and the ratio of men to women was 39:35. Atherosclerotic aortic aneurysm was concurrently observed in 21.1% in those 70 years or older, which was significantly higher than 5.6% in those younger than 70 years. Of 36 patients younger than 70 years, 27 (75.0%) were saved, compared with 18 of 38 patients (47.4%) 70 years or older. Surgical therapy was performed on 46 patients, 62.2%. The percentage of patients who underwent surgery was 69.4% in those younger than 70 years and 55.3% in those 70 years or older with no significant differences. Operative death occurred in 9 of 21 patients (42.9%) 70 years or older, which was significantly higher than the 12.0% (3 of 25) in those younger than 70 years. For 28 patients who did not receive surgical treatment, death occurred in 6 of 11 patients (54.5%) younger than 70 years compared with 10 of 17 (58.8%) 70 years or older with no significant difference: both rates were higher than 50% and 9 patients died of rupture during operative preparation. Since elderly people have a high risk for various complications and have poor operative results, it is important to carefully determine the therapeutic strategy, select a simple operative technique and conduct the operation as soon as possible.

Aortic Dissection Complicated by Atherosclerotic Aneurysm / 日本心臓血管外科学会雑誌

From January 1, 1999 through December 31, 2001, 152 cases of aortic dissection (77 cases of Stanford Type A and 75 Type B) were treated in our department. Among those cases, 25 patients (10 Type A (13.0%) and 15 Type B (20.0%)) were accompanied by atherosclerotic aneurysm. The mean age of onset of those cases was 71.4±9.8 years. Because those patients were older, it is necessary to pay attention to decide on treatment strategy and surgical procedure. In order to prevent atherosclerotic plaque being pumped into the brain vessel, we devised the following surgical procedure and perfusion method of cardiopulmonary bypass as follows; 1. In cases of retrograde perfusion from the femoral artery through the aneurysm, we usually pump the blood more slowly and gently than the antegrade perfusion. 2. We reduce the perfusion pressure after the heart beat changes to ventricular fibrillation. 3. After distal anastomosis of the vascular prosthesis, the blood is pumped from its perfusion branch. An initial tear was located in the spindle-shaped aneurysm in 3 cases (2.0%). Of 11 cases that aortic dissection was in contact with the atherosclerotic aneurysm, 2 cases of saccular shaped aneurysm terminated the dissection. In the 9 cases of spindle shaped aneurysm, however, the dissection involved the aneurysm, suggesting that the effect of aneurysm on the dissection depended on the aneurysmal shape. When the dissection coexists with aneurysm in different portions of the aorta, re-dissection may extend into the aneurysm. Therefore, careful decision making on the timing of surgery is necessary for abdominal aortic aneurysm complicated with aortic dissection, even when treating conservatively.

Fibrinogen Level and Its Influence on Cardiopulmonary Bypass in Surgery for Aortic Dissection / 日本心臓血管外科学会雑誌

For the purpose of reducing blood loss and blood transfusion, 100 cases of acute aortic dissection treated at this department were studied, focusing on surgery for aortic dissection and coagulation factors, fibrinogen in particular. In cases of aortic dissection, fibrinogen decreased at the acute stage, and showed concentrations significantly lower in Stanford Type A than in Stanford Type B, in extensive dissection (DeBakey Type I or Type III retrograde dissection) than in limited dissection (DeBakey Type II), and in open false lumen type than in closed false lumen type. In the assessment of 34 cases of acute Stanford Type A aortic dissection operated on within 24h of onset, it was found that a marked prolongation of activated clotting time (ACT≥1, 000s) during cardiopulmonary bypass causes an increase in blood transfusion. When ACT was maintained for 400s or longer, to inhibit the marked prolongation of ACT, by changing at any time the dose of heparin during cardiopulmonary bypass by 50-250units/kg on the basis of the preoperative fibrinogen level, instead of fixing it at 300units/kg, ACT decreased significantly, and was controlled at appropriate levels despite the low concentration of fibrinogen. As fibrinogen can be measured in the hospital, and the result obtained in a short time, it is considered to play an important role in controlling ACT to determine the dose of heparin based on its concentration.

A Case of Surgical Treatment for Type A Aortic Dissection Associated with Proximal Descending Thoracic Aortic Aneurysm / 日本心臓血管外科学会雑誌

A 63-year-old man suffered from type A acute aortic dissection associated with descending thoracic aortic aneurysm and coronary stenosis. He was treated surgically 49 days after onset of acute aortic dissection. Deep hypothermic selective cerebral perfusion was carried out for brain protection. It revealed the aneurysm, 51mm in diameter, located just distal to the aortic arch, and an intimal tear of the dissection located posterior wall of aneurysm. The total arch was replaced with 24mm vascular graft and CABG (LITA-to-seg. 8) was carried out. The postoperative course was uneventful and he was discharged on the 18th postoperative day.

A Case of Aortic Valve Replacement in Patient with Chronic Idiopathic Thrombocytopenic Purpura / 日本心臓血管外科学会雑誌

A 66-year-old woman with aortic stenosis and idiopathic thrombocytopenic purpura (ITP) underwent concomitant splenectomy and aortic valve replacement (AVR). High-dose trans-venous gamma-globulin therapy (400mg/kg/day) was performed for five days before surgery. The number of platelet, which was 6.0×10⁴/mm³ on admission slighty increased to 7.0×10⁴/mm³ before surgery. The aortic valve was replaced by an ATS 19mm prosthesis using cardiopulmonary bypass. Platelets were transfused postoperatively. Perioperative hemorrhage was moderate, and the postoperative course was uneventful. This was the second case we treated by concomitant cardiac surgery and splenectomy. It was safely performed after high-dose trans-venous gamma-globulin therapy.

Recurrent Suprarenal Abdominal Aortic Aneurysm(AAA) after Repair Infrarenal AAA / 日本心臓血管外科学会雑誌

We encountered a recurrent suprarenal abdominal aortic aneurysm (AAA) patient with coronary artery disease and hyperlipidemia after repair of infrareanal AAA. A 72-year-old woman complaining of an abdominal throbbing mass was admitted. Computed tomography (CT) and aortography revealed infrarenal AAA which was totally removed and Dacron graft was replaced. The patient was followed as an outpatient. At the time of initial graft replacement there was no remarkable aneurysmal change in suprarenal abdominal aorta. Five years after the initial operation, a suprarenal AAA 5cm in diameter was detected by ultra sonographic examination. CT scan and aortography confirmed suprarenal AAA involving the celiac trunk of the supramesenteric artery and renal artery. Redo AAA operation with reconstruction of these branches was performed under V-A bypass support in a thoracoabdominal approach. Slight renal and liver dysfunction occurred postoperatively. However, serum creatine GOT and GPT values normalized by the ninth postoperative day. Postoperative aortography revealed patency of all branches.