ABSTRACT
To study effects of clonidine on growth and plasma somatomedin C (SmC) lelvels, 42 male Wistar rats aged 28 days and weighing 75 to 105 g were given clonidine (1,5 microng/ml in drinking water), or filtered water alone and were weighed weekly. After 0,4 and 8 weeks, the animals were sacrificed under ether anesthesia, their length was measured and blood was collected by cardiac puncture for measurement of SmC concentration. Growth and the weigh/lengh ratio were lower, and plasma SmC levels (mean ñ SEM) were greater in the treated groups after 4 (616 ñ 44.7 vs 433.2 ñ 39.38 ng/ml, P < 0.01) and 8(595.2 28.3 vs 412.66 ñ 39.01 ng/ml, P < 0.01) weeks of treatment, suggesting that clonidine treatment increased growth hormone secretion. In other experiments, treated showed increased food intake only during the first week of treatment and decreased epididymal fat weight afther 3 weeks (1.412 ñ 0.0536 vs 1.6 ñ 0.1335 mg/100 g body weight, P < 0.01). The results suggest that clonidine acts at the level of the central nervous system involving transitory modulation of food intake, as well as on the regulation of energy metabolism
Subject(s)
Rats , Animals , Male , Clonidine/pharmacology , Feeding Behavior/drug effects , Growth/drug effects , Insulin-Like Growth Factor I/blood , Energy Metabolism , Rats, Wistar , Weight Gain/drug effectsABSTRACT
O diverticulo de Meckel como causa de abdomen agudo cirurgico e relativamente infrequente e devido a isso, o diagnostico no pre-operatorio quase nunca e realizado.Os autores fazem um analise de oito pacientes operados no Servico de Emergencia do Hospital de Base do Distrito Federal. Em cinco casos a complicacao encontrada foi obstrucao intestinal por brida que partia do diverticulo, em dois casos ocorreu perfuracao do diverticulo sendo demonstrado histologicamente mucosa gastrica heterotopica e o paciente restante teve volvo do diverticulo com necrose, hemorragia e perfuracao do mesmo
Subject(s)
Child , Adolescent , Adult , Humans , Male , Female , Abdomen, Acute , Meckel DiverticulumABSTRACT
Os autores tecem comentarios sobre a sindrome da sela vazia, principalmente sobre o aspecto da secrecao endocrina nesses pacientes e apresentam dois casos de suas observacoes. Um dos casos nao apresentava alteracoes na secrecao endocrina, apesar da infertilidade secundaria de 12 anos e polimenorreia. O outro caso tinha prolactina basal alta e nao respondeu ao teste da L-Dopa