Urinary glutathione transferase [G.S.T]: a marker for post transplant cytosporine A induced renal tubular lesions

In this study, 50 renal transplant patients [RTx] and ten normal controls were investigated for the urinary GST-pi levels. All RTx were on cyclosporine A and were classified according to the duration of post transplant into group I [11 patients], group II [23 patients], group III [nine patients] and group IV [seven patients]. The data showed a significant increase of GST pi in RTx compared with the controls. RTx subgroups showed a significant increase in GST compared with the controls. Comparing RTx subgroups together showed nonsignificant changes in GST between GI and GII, GIII and GIV despite a significant decrease in CyATL and nonsignificant changes in SCr