ABSTRACT
Spontaneous pneumothorax is a rare complication of pulmonary metastatic disease, most often following chemotherapy for osteogenic sarcomas, primary lung cancer or malignant germ cell tumors. Intensive chemotherapy may theoretically increase the risk of pneumothorax in patients with manifest or occult lung metastases by inducing rapid lysis of the tumor tissue and by interfering with repair processes. We present a case of patient with spontaneous pneumothorax after the introduction of chemotherapy for metastatic choriocarcinoma and review the literature and discuss the possible pathophysiologic mechanisms.
Subject(s)
Female , Humans , Pregnancy , Choriocarcinoma , Drug Therapy , Lung , Lung Neoplasms , Neoplasm Metastasis , Neoplasms, Germ Cell and Embryonal , Osteosarcoma , PneumothoraxABSTRACT
Abdominal wall endometriosis secondary to cesarean section is very rare condition, being reported in less than 0.5% of patients undergoing cesarean section. Moreover, parenchymal pulmonary endometriosis is a rare gynecologic problem, characterized by cyclic hemoptysis. We experienced 38 years old female patient who had had cyclically appearing painful abdominal wall mass after cesarean section pathologically proven endometriosis and 33 year-old female patient with recurrent catamenial hemoptysis localized with CT scanning, and then treated with GnRH agonist. So, we present two cases with a brief review of literatures.
Subject(s)
Adult , Female , Humans , Pregnancy , Abdominal Wall , Cesarean Section , Cicatrix , Endometriosis , Gonadotropin-Releasing Hormone , Hemoptysis , Tomography, X-Ray ComputedABSTRACT
OBJECTIVE: This study is to investigate whether Positron Emission Tomography (PET) is useful for determining pathologic complete response in patients with ovarian carcinoma who had a clinical complete response after primary treatment. METHODS: FDG-PET scans were performed in 10 patients with advanced ovarian cancer (4 patients with stage IIC, 6 patients with IIIC), who showed complete response with cytoreductive surgery and 6 cycles of post-operative adjuvant Cisplatin-based combination chemotherapy. FDG-PET scan was obtained with GE Advance Scanner, beginning at 50 minutes after injection of 370-555 MBq (10-15 mCi) of 18F FDG. Uptakes exceeding 3.5 SUV (Standardized Uptake Value) or larger than surrounding tissue were determined as a positive findings. Second-look laparotomy was undertaken within median 4 days after FDG-PET scanning. RESULTS: The mean age of the patients was 45 years and serous cystadenocarcinoma was most common histologic type. None showed active lesion in pelvis or abdomen with FDG-PET scan (SUV: >3.5 kg/ml), however, 5 patients (50%) showed residual tumors on multiple biopsy during second look operation. One patient showed positive lesion in lung on FDG-PET scan, which was confirmed to have metastatic lesion. CONCLUSION: FDG-PET scan is not useful for detection of small ovarian cancer lesions in pelvis and abdomen and cannot substitute for second-look operation to determine pathologic complete response.
Subject(s)
Humans , Abdomen , Biopsy , Cystadenocarcinoma, Serous , Drug Therapy, Combination , Laparotomy , Lung , Neoplasm, Residual , Ovarian Neoplasms , Pelvis , Positron-Emission TomographyABSTRACT
Malignant germ cell tumors of the ovary are rare gynecologic tumors usually affecting younger women. Recently, we experienced a case of 11-year old female with mixed germ cell tumor of ovary which was composed of yolk sac tumor and immature teratoma with high serum levels of alpha-fetoprotein (AFP) and human chorionic gonadoprotein (hCG). We report this case with brief review of concerned literature.