Susceptibility Weighted Imaging in Acute Stroke with Co-morbids: Magnetic Resonance Imaging Protocol Revisited

Introduction:We aim to investigate ischemic penumbra using Diffusion weighted imaging-Susceptibility weighted imaging mismatch using DWI Alberta Stroke Program Early Computed tomography Stroke Score scoring in patients with multiple co morbid.Methods:From January 2011 to December, 2017; 70 consecutive patients (50 men, 20 women; mean age 64.5; range 45-82 years) with acute infarct on Diffusion weighted imaging (DWI) were selected for the study. Stroke protocol performed including DWI and susceptibility weighted imaging (SWI) on first day and repeat within three days. All initial MR images were interpreted by one Neuroradiologist with more than ten years blind to the clinical findings of each patient. The definition of an acute infarct area was high signal intensity on DWI with dark signal intensity on Apparent diffusion weighted imaging (ADC). The infarct extent was scored using the Alberta Stroke Program Early CT Score (ASPECTS) system. Infarct growth was defined as any new or larger lesion on the second DWI.For correlation with infarct growth, the same topographic system was used to record the extent of the Prominent vessel sign(PVS) on SWI.Spearman’s rank correlation test was used to examine the correlations between PVS score and infarct growth score. Regression was computed, with P<0.05 considered significant.Results:The study included 12 women and 10 men, (mean age 67.1 years).MRI images were initially acquired as stroke protocol (mean 12 hours) in acute stage and the next MRI was done within 3 days after the acute stage.9 patients had right sided and 13 patients had left sided MCA territory infarct, the mean DWI-ASPECTS score was 4.3 (range 0–9). PVS was detected in 15 patients (mean score 4.1, range 0–10).Out of 22 patients 9 patients showed no evolution in infarct however in 13 patients evolution was from (ASPECTS mean score 3.95, range 0–9; mean infarct growth score 7.4, range 0–10).7 patients devoid of PVS in initial MRI, did not exhibited evolution of infarction. Of 15 patients with PVS on initial MRI, 13 (87%) had infarct growth. Correlation between the evolution in infarct size and PVS score was observed (r = 0.86,P<0.001).Conclusion:PVS seen in infarcted territory is related to poor prognosis and this can be reliably used as a surrogate marker of oxygen extraction in penumbra.SWI can predict tissue at risk and can be a replacement for perfusion scan in clinical scenerio of acute ischaemic infarct

Accuracy of hyperintense cerebrospinal fluid signals (CSF) on inversion recovery (IR) images of brain in the diagnosis of meningitisa cost effective experience from third world country.

Objective: To detect the diagnostic accuracy of inversion recovery sequence in detection of meningitis taking cerebrospinal fluid as the gold standard. Material and Methods: This study was conducted in Aga Khan University Hospital (AKUH) Karachi. Retrospective data was reviewed from 1ST November 2010 to 31st November 2012. All consecutive patients who came with clinical diagnosis of meningitis were included. Fifty patients were included in study on the basis of inclusion and exclusion criteria. Two independent neuroradiologists retrospectively reviewed FLAIR sequences blinded to CSF findings. Their findings were compared with cerebrospinal fluid results. Sensitivity, specificity, PPV, NPV and diagnostic accuracy were calculated. Results: Hyperintense CSF signals on FLAIR sequence found to have 94.7% sensitivity, 83.3% specificity and accuracy of 92% in diagnosis of meningitis while PPV and NPV were 94.7% and 83.3% respectively. Conclusion: We found that hyper intense CSF signals on FLAIR sequence has high accuracy in diagnosis of meningitis.