ABSTRACT
Drug administration can be done through different ways like injection, topical application, phonophoresis and iontophoresis. The aim of this study was to determine the effect of drug administration by iontophoresis and injection of 2% lidocaine with 4% dex methasone sodium phosphate on pain perception, active range of motion [AROM], motor distal latency [MDL], and motor conduction velocity [MCV] of the median nerve in people with acute unilateral carpal tunnel syndrome [CTS]. Thirty subjects with acute unilateral CTS participated in this study. The results of this study showed significant improvement of wrist movement and reduction in pain and MDL in the acute CTS in treated groups versus control group. The results of this study may suggest the following: 1- The severity of symptoms does not correlate with severity of electrodiagnostic abnormalities. 2- lontophoresis may be considered as a preferable treatment technique in people with acute CTS