Synthesis, antibacterial and antifungal possession of amino acids containing sulfonamide moieties

Sulfonamides were developed by the simple reaction of amino acid with p-toluenesulfonyl chloride and structures of the new products [2a, 2b and 2c] were confirmed by elemental and spectral analysis [FT-IR, [1]HNMR and[13]CNMR]. In vitro, developed compounds were screened for their antibacterial and antifungal activities against two sensitive bacteria belonging to both gram positive and gram-negative types and two fungi. The synthesized sulfonamides [2a, 2b, 2c] exhibited excellent antifungal activities against the tested fungi. Among the tested compounds 2a and 2b have marked activity against E. coli with zone of inhibition [mm] 22.3+/-0.11and 20.2+/-0.26 [MIC: 12.5[micro]g/mL, 12.5[micro]g/mL] and S. aureus with zone of inhibition [mm] 20.2+/-0.26 and 23.2+/-0.55 [MIC: 12.5[micro]g/mL, 6.25[micro]g/mL]. Compound 2c is moderately efficient towards E. coli [zone of inhibition [mm] 14.2+/-0.64, MIC: 100[micro]g/mL] and no activity against S. aureus

Synthesis, antimicrobial and antifungal possessions of tramadol esters: In vitro studies

Tramadol esters were prepared by refluxing equimolar concentration of tramadol with leucine and asparagine separately with methanol, sulphuric acid and phthalic anhydride for 10 hours and temperature was maintained at 75[degree]C. After refluxing, the colour of sample solutions were changed from colorless to yellow, blank solution was prepared in the same way as the sample solution except the Tramadol. Both the products and blank were neutralized with sodium carbonate and excess of sodium bicarbonate was precipitated as sodium sulphate, which was washed with acetone. The structures of both the products were confirmed with spectral data [FT-IR, [1]HNMR and [13]CNMR]. Antimicrobial and anti-fungal property of derivative of analgesic tramadol drug was tested with one fungus and three sensitive bacteria belonging to both gram positive and gram-negative types. Esterified product of tramadol with leucine and asparagine showed moderate activity against Escherichia coif and Tricophyton rubrum. Both the products showed marked activity against Staphylococcus aureus and found no activity against Salmonella spp