ABSTRACT
Objective: To investigate the effect of Beri-honey-impregnated dressing on diabetic foot ulcer and compare it with normal saline dressing
Study Design: A randomized, controlled trial
Place and Duration of Study: Sughra Shafi Medical Complex, Narowal, Pakistan and Bhatti International Trust [BIT] Hospital, Affiliated with Central Park Medical College, Lahore, from February 2006 to February 2010
Methodology: Patients with Wagner's grade 1 and 2 ulcers were enrolled. Those patients were divided in two groups; group A [n=179] treated with honey dressing and group B [n=169] treated with normal saline dressing. Outcome measures were calculated in terms of proportion of wounds completely healed [primary outcome], wound healing time, and deterioration of wounds. Patients were followed-up for a maximum of 120 days
Results: One hundred and thirty six wounds [75.97%] out of 179 were completely healed with honey dressing and 97 [57.39%] out of 169 wtih saline dressing [p=0.001]. The median wound healing time was 18.00 [6 - 120] days [Median with IQR] in group A and 29.00 [7 - 120] days [Median with IQR] in group B [p < 0.001]
Conclusion: The present results showed that honey is an effective dressing agent instead of conventional dressings, in treating patients of diabetic foot ulcer
ABSTRACT
Methicillin resistant Staphylococcus aureus [MRSA] continues to be one of the commonest pathogens encountered in clinical as well as laboratory practice. It has become a major health problem worldwide. Newer antimicrobials/agents are urgently needed to combat this problem MRSA resistance to various anti-staphylococcal agents. In the back-drop of this difficult situation Nigella sativa commonly known as black seed [ethanolic extract] was aimed at to evaluate if it had any anti-staphylococcal activity. The extract was prepared by reflux extraction method. Disc diffusion and in agar dilution methods were performed to assess the antibacterial activity. Staphylococcus aureus ATCC 25923 was used as the standard reference strain. All tested strains of MRSA were sensitive to N. sativa extract at a concentration of 4 mg/disc while the extract had an MIC range of 0.2-0.5 mg/ml. The results indicated that N. sativa has inhibitory effect on MRSA. This finding warrants necessity of further investigation of this product of folk medicine