ABSTRACT
An antifungal compound 9, 10-dihydrophenanthrene - 2 - carboxylic acid was isolated from a marine derived bacterium Pseudomonas putida isolated from surface water samples of Karachi fish harbor coast line. The structure was explored using extensive 1D- and 2D-NMR spectroscopic techniques. The compound was found to be active against fungal strains obtained from clinical samples whereas strong activity was noted against Candida albicans with a MIC value of 20microg/ml, as the purified compound showed promising anticandidal activity a multidisciplinary approach is needed to explore further this compound as potential pharmacological lead compound against Candida spp and will add in the global hunt for clinically functional antifungal agents
ABSTRACT
Background: This study was conducted to compare the effects on intraocular pressure and side effects of monotherapy with either latanoprost or dorzolamide in patients with open angle glaucoma, pseudoexfoliation glaucoma or ocular hypertension
Methods: Sixty patients with open angle glaucoma or ocular hypertension were recruited to a 3-month study. Previous glaucoma medications were washed out and the patients were randomised to receive either latanoprost 0.005% once daily or dorzolamide 2% three times daily. The follow-up visits were conducted at two weeks, one months and three months of study and intraocular pressures and slit lamp examinations were carried out to look for response of therapy and detect complications
Results: After 3 months, latanoprost reduced mean baseline intraocular pressure from 27.2+/-3.0 mm Hg by 8.5+/-3.3 mm Hg. The corresponding figures for dorzolamide were 27.2+/-3.4 and 5.6+/-2.6 mm Hg. The difference of 2.9 mm Hg [95% CI: 2.3-3.6] was highly significant [p<0.001]. Both drugs were well tolerated systemically and locally
Conclusion: Latanoprost was superior to dorzolamide in reducing the intraocular pressure, judged from the effect on mean intraocular pressure. The once daily dose in the evening ensures better compliance and the problem of hyperpigmentation of the iris were not encountered
ABSTRACT
This study was conducted at Eye department Military Hospital Rawalpindi. One hundred cases were randomly selected and grouped into two namely A and B. Group A received 1 mg of nalbuphine and in Group B surgery was performed without any intravenous sedative or analgesic. Visual Analog Scale was used to measure the pain intensity. Our study has shown that forty patients in Group A had no pain following injection of Nalbuphine as compared to zero patients in Group B [p<0.001]. Similarly ten patients in Group A had mild pain following injection of Nalbuphine as compared with 27 patients in Group B [p<0.005]. According to this study it was found that 1 mg of nalbuphine provides adequate pain relief