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1.
Pakistan Journal of Pharmaceutical Sciences. 2018; 31 (5): 1889-1897
in English | IMEMR | ID: emr-199571

ABSTRACT

Effect of solvent polarity and extraction time on antioxidant properties of Brassica oleracea seeds was optimized by response surface methodology using central composite design. A significant linear negative effect of solvent polarity on total extractable components [TEC], total phenolic acids [TPA], linoleic acid reduction capacity [LARC] and hydroxyl radical scavenging capacity [HRSC] and significant positive effect on iron chelating activity [ICA], reducing power [RP] and [DPPH RSC]. Linear effect of solvent polarity on total antioxidant activity [TAOA] was also found to be positive but not significant. Significant linear negative effect of extraction time was observed on ICA and HRSC. Only RP was found to be significantly increased with increase in extraction time. Quadratic effect of solvent polarity was found to be negative on TAOA, DPPH RSC and HRSC. However, quadratic effects of both variables were found to be positive on TEC, TPA, ICA and LARC. The polarity dependent increase in TAOA indicates the extraction of phytochemicals with comparatively stronger antioxidant properties in polar solvents. The decrease in antioxidant properties in response to increase in extraction time may be attributed to the time dependent loss of antioxidant activity of extracted compounds

2.
Pakistan Journal of Pharmacology. 2004; 21 (1): 37-40
in English | IMEMR | ID: emr-204804

ABSTRACT

To compare the effects of two dietary monounsaturated oils on plasma lipid profile in Albino rats, thirty-six Albino rats were divided into three groups. Each group was fed a diet containing a different dietary oil for 12 weeks Lipid profiles of control, rapeseed oil group and olive oil group at 0-week and 12 weeks were estimated. Results showed that in olive oil group, there was a non-significant [P>0.05] decrease of 3.8% in TC, significant [P<0.005] decrease of 12% in LDL-c, 18% in VLDL-c 17% in TAG, 8.5% decrease in it levels. There was a significant increase of 21% in HDL-c levels. In Rapeseed oil group, there was a non-significant decrease of 26% in VLDL-c, 3.6%, in TAG, 1.8% in TL levels; there was a significant increase of 11.6% in TC, 20.8% in LDL-c 14.3% in HDL-c levels. We conclude that not all monounsaturated oils have the same effects on serum lipid profile. In this study, olive oil diet corrected the lipid profile mere beneficially as compared with the rapeseed oil

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