ABSTRACT
Objectives: To compare the efficacy of Metformin with insulin in gestational diabetes mellitus in terms of fetomaternal outcome
Study Deign: Randomized clinical trial study
Setting: Lady Aitchison Hospital Lahore
Period: January 2014 to March 2015
Methodology: Total 500 pregnant females with GDM were included in the study through nonprobability, consecutive sampling. Patients were divided into 2 equal groups [A: B]. Patients in group A were given tablet metformin 500 mg by oral route and group B was administrated regular injection Insulin by subcutaneous route
Results: The mean age of females was 32.14 +/- 6.13 years. The mean gestational age was 31.07 +/- 3.8 weeks. There were 78 [15.6%] females who had 0 parity, 107 [21.4%] females had parity 1, 175 [35%] females had parity 2, 95 [19%] females had parity 3, 33 [6.6%] females had parity 4 and 12 [2.4%] females had parity 5.There were 54 [10.8%] cases had PTB, out of which 12 [4.8%] had PTB with metformin while 42 [16.8%] had PTB with insulin. There were 115 [23%] neonates required NICU admission, out of which 37 [14.8%] neonates with metforminand78 [31.2%] neonates with insulin. There were 87 [17%] neonates who had neonatal hypoglycemia, out of which 23 [9.2%] neonates with metformin and64 [25.6%] neonates with insulin. The difference was significant between both groups for all fetal outcomes [P<0.05]
Conclusion: The metformin is more effective in preventing adverse fetal and maternal outcome as compared to insulin