ABSTRACT
Objective: To find out the frequency of different pathologies causing enlarged cervical lymph nodes
Study Design: A Prospective observational study
Place and Duration: Study carried out from 1[st] Jan 2006 to 31[st] Dec 2006 at ENT Department of Khayber Teaching Hospital, Peshawar, Department of Pathology Kabeer Medical College, Peshawar and Department of Histopathology, Combined Military Hospital Peshawar Cantonment
Methodology: The patients presenting with cervical lymph node enlargement for more than one month duration were subjected to Fine Needle Aspiration. A Core Needle or open biopsy was performed when FNAC yielded a non diagnostic aspirate or when a histological confirmation of a malignant tumour was required
Results: A total of 116 patients, aged between 8-72 years with a mean age of 34.64 and male to female ratio of 1.23:1 were studied. Tuberculosis was the commonest cause of lymphadenopathy 36.2% [n=42], followed by metastatic disease 29.3% [n=34], reactive hyperplasia was the third commonest cause with 19.3% [n=22], followed by Lymphoma [both Non Hodgkin's and Hodgkin's] accounting for 13.8% of cases. A single case 0.86% of Kikuchi's or Necrotizing lymphadenitis was also found
Conclusion: Tuberculosis was the underlying cause in younger patients while metastatic disease was more commonly found in elderly patients
ABSTRACT
To determine the frequency of G6PD deficiency in asymptomatic Pakistan population. Cross sectional study. This was carried out at Pakistan Air Force [PAF] Hospital at PAF Base Masroor Karachi between June 2004 - September 2007. Healthy young males and females between the ages of 13 to 28 years were tested for G6PD deficiency. None of the individuals had the findings of chronic hemolytic anemia. Their test was carried out on Trinity Biotech visual, qualitative, colorimetric procedure for determining G6PD deficiency using dichlorophenol indophenols as an indicator. During the study period 888 individuals, 804 males and 84 females were tested for G6PD deficiency. Forty [4.5%] individual had G6PD deficiency. All were otherwise healthy with normal general physical examination, complete blood count, blood glucose level, liver function tests, renal function tests, lipid profile, urine analysis, electrocardiogram and X- Ray chest .Out of 804 males 40[5.0%] had G6PD deficiency. None of the 84 females had the enzyme deficiency. G6PD deficiency is observed to be 4.5%. Our findings are in conformity with W.H.O data for geographic distribution of G6PD deficiency in Pakistan .It should be considered in the differential diagnosis of hemolytic anemia, especially following drug administration