ABSTRACT
Today diabetes is a global problem. Insulin play an inportant role in the lipid and lipoprotein metabolism. Glycemic control improves and may even normalize triglyceride and HDL cholesterol level in diabetic petients, therefore one could speculate the improvement of glycemic control beneficidly influence LDL phenolype. The degree of hyperglycemia was assesed by means of measmement of fasting blood glucose and glycosylated heamoglobin [Haemoglobin A[1c]. To compare the lipid profile in good glycemic controlled NIDDM type 2 with glycemic uncontrolled NIDDM type 2 and matched controls. Comparative study. This study was conducted at BMSI, JPMC, Karachi from June 2007 to December 2007. Total 120 subject of either sex, age were included with set criteria in study and were distributed in to three groups. Group A controls, Group B glycemic controlled type 2 NIDDM using oral hypoglycemic drugs regularly - Group C glycemic uncontrolled type 2 NIDDM using oral hypoglycemic drugs regularly. Lipid, lipoprotein and fasting serum sugar and HbA[1c] were analyzed. Highly significantly increase in total cholestrol, triglycerides and LDL cholestrol, while significantly decrease in HDL cholestrol in glycemic uncontrolled type 2 NIDDM . Fasting serum glucose level and HbA[1c] are useful diagnostic index for glycemic controlled and uncontrolled type 2 NIDDM - patient with glycemic uncontrolled type 2 NIDDM have greater disbances in lipid and lypoprotein metabolism which leads to atherosclerosis which futher results in coronary, cerebral and peripheral vascular occlusion