ABSTRACT
Amoebiasis is a worldwide disease, particularly common in tropical countries and places where public hygiene and sanitation are poor. Amoebic infection is caused by an organism, Entamoeba histolytica [E.H.] that usually spreads through contaminated food and water. Since the causative organism of amoebiasis derives its nutrition from the normal bacterial flora of the large intestine, the latter is the chief site of infection. Aim of the study is to decrease the prevalence of Amoebic Dysentery in the community by trusted and cost-effective herbal medicinal preparation. Clinical evaluation of amoebiasis and its treatment was undertaken to evaluate the therapeutic efficacy of herbal coded medicine Amoebin Cap along with a comparative study of another Herbal Medicine Endemali, an Allopathic Medicine Entamizole DS and placebo. A randomized, clinical, comparative study has been conducted between the formulated herbal medicine Amoebin Cap, allopathic medicine Entamizole DS, herbal proprietary product Endemali and placebo to provide clinically evidence based assessments. Amoebin Cap comprises of herbs such as Phyllanthus emblica, Aegle marmelos, Holarrhena antidysenterica and Myrtus communis. The clinical evaluation involved quite a number of patients living in Karachi around 202 patients selected for the final diagnosis and treatment of amoebiasis. The clinical trial was conducted to assess the drugs and the details of which are given along with tables with its graphic representations. The number of patients assigned to test group that is Amoebin Cap were 80, while in control group 63 patients were registered to Entamizole DS and 50 patients for Endemali along with this 9 patients were kept on placebo. The data was collected in the years from 2001-2004. There were total 202 patients, the frequency of male patients were 127 [percentage of male 62.9%] while, 75 of female patients [percentage of female 37.1%] were enrolled into the study. Using a Chi-Square Test and Fisher Exact Test statistical analyses were made. All patients which were treated with Amoebin Cap showed improvement. Out of 63 patients who were treated by Entamizole DS 58 showed improvement and five did not. After applying the test of significance there was significant difference between these two drugs. Fisher Exact Test was applied and p-value was calculated as 0.015 while comparing Amoebin cap with Endemali 50 patients treated with an herbal drug Endemali. Results revealed that all patients, which were treated with Amoebin Cap, showed improvement, and out of 50 patients who were treated by Endemali 30 showed improvement and twenty did not. After applying the test of significance there was highly significant difference between these two drugs with Chi-Square Test was deduced [Yates correct] 34.81 and p-value was found to be 0.000