ABSTRACT
Diet is the main factor affecting serum lipid concentrations. We studied the changes in serum lipid profile by high fat sunflower oil diet. We also documented the effects of Nigella Sativa [Kalonji] on serum lipid profile. Thirty two albino rats were divided into two groups i.e. one control [C] groups and other experimental [E] group having equal number of rats. Study was carried out for twelve weeks. Fasting blood samples were drawn by heart puncture for serum lipid profile under ether anaesthesia. Estimations were done by recommended methods. Statistical methods were done by using student's "t" test. We found decrease in total cholesterol by 9.6%, triglyceride by 4.21%, LDL cholesterol by 12.0% and HDL cholesterol by 10.4%. We concluded from study that polyunsaturated fatty acid in high concentrations [20%] has lipid-lowering effect and Nigella sativa has got HDL cholesterol raising effect, which has anti-atherogenic potential
ABSTRACT
Diet influences serum levels of total cholesterol, triglyceride and individual lipoproteins. We compared the serum lipid changes in albino rats fed on low fat sunflower oil diet and Nigella Sativa. Thirty two albino rats were divided into two groups, one control [C] group fed on low fat sunflower oil and other experimental [E] group fed on low fat sunflower oil diet and Nigella Sativa. The study was carried out for twelve weeks. Fasting blood samples were taken by heart puncture under ether anaesthesia for serum lipid profile. Estimations were carried out by recommended methods. Statistical methods was done by using students's "t" test. We found an increase in total cholesterol, triglyceride, high-density lipoprotein cholesterol [HDL-c] and low-density lipoprotein cholesterol [LDL-c]. We concluded from the study that polyunsaturated fatty acids in low proportions and Nigella Sativa has HDL-c raising effect, which has anti-atherogenic potential