ABSTRACT
Noise is an ever growing problem in modern society. Apart from its effect on hearing, behavior, and mood it also has a potent effect on immune system. Therefore the present study was designed to asses' effect of chronic noise stress on mantle zone [MnZ] of lymphoid follicle [LF] of spleen in albino rats. Two groups of twenty rats, each group labeled A and B were used; serving as control [no noise] and noise stress [30 days] respectively. Group B was exposed to noise stress of 100 dB for 30 day [3-4hrs/day]. Animals were sacrificed at the end of study, spleen was removed prepared, sectioned and stained with CD79a. A highly significant decrease in mean no of cell in MnZ of LF was observed [1 5747 +/- 87.82/mm[2]] in noise stressed group when compared with MnZ of control animals [16567 +/- 106/mm[2]]. There was also a highly significant increase in mean perimeter of nuclei observed in MnZ of stressed group [2.74 +/- 0.009pm] when compared with rats of control group [2.68 +/- 0.01microm]. Our study concludes that noise stress induced release of glucocorticoid can significantly decrease number of B lymphocytes in MnZ of LF of spleen in albino rats
ABSTRACT
Noise is an ever growing problem in modern society. Apart from its effect on hearing, behavior, and mood it also has a potent effect on immune system. Therefore the present study was designed to asses effect of chronic noise stress on mantle zone [MnZ] of lymphoid follicle [LF] of spleen in albino rats. Two groups of twenty rats, each group labeled A and B were used; serving as control [no noise] and noise stress [30 days] respectively. Group B was exposed to noise stress of 100 dB for 30 day [3-4hrs/day]. Animals were sacrificed at the end of study, spleen was removed prepared, sectioned and stained with CD79a. A highly significant decrease in mean no of cell in MnZ of LF was observed [15747 +/- 87.82/mm[2]] in noise stressed group when compared with MnZ of control animals [16567 +/- 106/mm[2]]. There was also a highly significant increase in mean perimeter of nuclei observed in MnZ of stressed group [2.74 +/- 0.009microm] when compared with rats of control group [2.68 +/- 0.01microm]. Our study concludes that noise stress induced release of glucocorticoid can significantly decrease number of B lymphocytes in MnZ of LF of spleen in albino rats
Subject(s)
Male , Animals, Laboratory , Spleen , Rats , B-Lymphocytes , CD79 AntigensABSTRACT
To find out incidence of H. pylori anti bodies in non ulcer dyspepsia patients admitted in people's medical college hospital, Nawabshah. A prospective study was conducted at Department of medicine, unit III peoples medical college hospital, Nawabshah from March 2003 to Oct 2004. The patients admitted in medical unit-3 in PMCH, Nawabshah with dyspeptic symptoms. Any organic disease was excluded by upper G I T endoscopy. H. pylori antibodies were done by kit method. A total of 100 patients were taken. 60% were female and 40% were male. H. pylori antibodies were positive in 45 [45%] subjects. H. Pylori is significantly positive in non-ulcer dyspepsia patients. So every patient of non ulcer dyspepsia should be evaluated for H. Pylori antibodies