ABSTRACT
Chemical constituents of functional importance as acid phosphatase, alkaline phosphatase, citric acid, ascorbic acid, zinc and fructose from accessary sex organs of rats were observed in normal, prolonged alloxan diabetic and orally glibenclamide treated prolonged diabetic rats. Diabetes mellitus when persisted for longer time caused gross atrophy of accessory sex glands and glibenclamide treatment did not improve the glandular weight and morphology. Acid phosphate and citric acid concentration increased in untreated diabetic animals and was found further elevated in the diabetic treated with glibenclamide. Alkaline phosphatase and ascorbic acid concentrations, however, decreased on glibenclamide administration. The glandular zinc concentration remained unchanged in all the experimental groups. The fructose showed a non-significant increase in the accessory sex glands of untreated diabetic rats