ABSTRACT
The objective of this study was to assess the levels of C-reactive protein in type-2 diabetes mellitus patients in the local population. Serum samples of patients of sixty type-2 diabetes mellitus and thirty healthy subjects acting as control of same age and sex matched were included from the general community, ensuring similarities of their basic confounding factors. Duration of type-2 diabetes of these subjects was also recorded. Sera were stored at-80°C till analysis. Estimation of CRP was done by a microplate immunoenzymometric assay. HbAlc levels in blood were done by using a commercial kit. Baseline values for HbAlc and CRP were assayed in the diabetic as well as control samples. CRP levels in serum were significantly higher among diabetic participants compared to the control subjects [P<0.05]. Among diabetic participants, higher levels of HbAlc were associated with higher level of CRP. CRP levels during different duration of type-2 diabetes were 3.4 +/- 1.35 micro g/ml in type-2 diabetics and 1.37 +/- 1.10 micro g/ml in control subjects having duration less than one year [P<0.05] similarly, 1-5 years 6-10 years and 11-15 years of duration had levels 4.90 +/- 1.57 micro g/ml, 4.60 +/- 1.90 micro g/ml and 4.42 +/- 1.20 micro g/ml respectively in type-2 diabetics and control subjects had 1.85 +/- 1 .20 micro g/ml, 1.40 +/- 1 .70 micro g/ml and 1.22 +/- 1.10 micro g/ml respectively. Diabetes having 16-20 years duration showed a non significant behavior. Our findings show that patients having type 2 diabetes had higher CRP levels in serum compared to the control subjects. Duration of disease and HbAlc levels showed statistical significant differences