ABSTRACT
To determine the presence of diabetes mellitus and other conventional coronary heart disease risk factors such as hypertension, hyperlipidemia and sedentary lifestyles in patients with acute coronary events in Pakistani population. This study included 300 type-2 diabetic patients selected from diabetic clinic of PMRC Research Centre Fatima Jinnah Medical College and Sir Ganga Ram Hospital Lahore with insulin resistant type-2 diabetics, unstable angina or myocardial infarction [MI]. One hundred and fifty control subjects without diabetes, myocardial or other coronary artery disease were also included in this study. Out of all patients 41.66% were female while 58.34% males and duration of diabetes was 0-3 years in 8% cases. Frequency of cardiovascular complications in type-2 diabetics were noted in 40.66% having hypertension, angina pectoris in 12.33%, congestive cardiac failure in 2% and MI in 2% cases. Location and extension of MI and myocardial enzymes did not differ between diabetics and non-diabetic patients. Age, duration of diabetes and HbA1c levels, did not differ between diabetic patients with or without MI. Hypertension and current smoking was significantly higher in patients with MI compared to patients with unstable angina [P< 0.05]. Serum TG, HDL-C, LDL-C and total cholesterol level did not differ between patients with MI and unstable angina. In this study insulin resistant type-2 diabetic patients have at least one of conventional cardiac risk factors. Diabetes and hypertension are leading risk factors, which may directly or indirectly interfere and predict more serious complications of coronary heart disease