ABSTRACT
Hypertensive disorder of pregnancy affecting multiple systems and woman has dangerously high blood pressure, swelling, and protein in the urine. Therefore serum albumin and uric acid are useful biochemical markers reflecting the severity of the occurrence of preeclampsia and eclampsia. Objective: The aim was to study the role of albumin and uric acid in preeclampsia and eclampsia. Methods: This is the case-control hospital based study carried in the Grant Government Medical College and Sir J.J. Group of Government Hospitals, Mumbai. Normotensive pregnant women (n=50) and women with preeclampsia (n=50) and eclampsia (n=50) were included in the study. Both the groups were in their third trimester and of same age and same gestational age. Serum albumin and uric acid were estimated by BCG endpoint and Uricase – PAP method respectively. Result: The alterations of serum albumin and uric acid levels in preeclampsia and eclampsia pregnant subjects were found as compared to those of control group. A negative and significant correlation (r = -0.492 and -0.602, p < 0.001) was observed between serum albumin with uric acid in study subjects. Conclusion: The results suggest that, albumin and uric acid are important factors in the pathogenesis of preeclampsia and eclampsia and are directly related to the severity of disease.