ABSTRACT
Background: Proton pump inhibitors are substituted benzimidazoles compounds, they are used as agents for the treatment of acid-peptic diseases. These compounds are metabolized by several enzymes, the genetic variations in these enzymes were thought to influence the pharmacogenetics of the proton pump inhibitors and in turn influence the outcome of the patients
Aim: To highlight the pharmaco-genetics of proton pump inhibitors
Methods: Scientific websites were used to search for articles such as Pubmed and Google Scholar. Several keywords were used to obtain all possible articles concerned with the subject
Results: We reviewed 6 articles about the current subject, there were few articles about the pharmacology of proton pump inhibitors
Conclusion: Few studies have focused on the pharmacogenetics of proton pump inhibitors and most of them were trials, also there were no previous review articles studied this subject
ABSTRACT
Background: urinary incontinence is a distressing common medical disease in which patient cannot control leakage of urine. The prevalence of urinary incontinence differs between countries and between different studies. The risk factors for urinary incontinence including increasing age, chronic cough, medical co-morbidity, childbirth, obesity, depression, smoking, gender and previous hysterectomy
Aim of the work: this study aimed to assess the prevalence of urinary incontinence in Saudi females and its associated risk factors
Methods: this was a cross-section study based on a survey on the internet, it included 400 female participants with a minimum age of 30 years old
Results: the prevalence of urinary incontinence was 44.25%, 66.3% of them were in age of 50 years and above. 43.5% of participants were obese, 19.5% were post-menopausal, 6.25% performed hysterectomy, 37.5 % had parity more than 3 times, 33% had depression and 35.5% had diabetes
Conclusion: prevalence of urinary incontinence was moderate. The most common risk factors for urinary incontinence were older age, menopause and high parity