ABSTRACT
Objective: To study platelet counts [PC], mean platelet volume [MPV] and glycated HbA1 in type 2 Diabetes mellitus [T2DM]
Study Design: Case control study
Place and Duration of Study: This study was conducted at the Department of Medicine, Indus Medical College Hospital, Tando Muhammad Khan, Sindh from March to November 2015
Materials and Methods: A sample of 150 subjects; comprising of Group A- controls [n=50], Group B- controlled diabetics [n=50] and Group C- [n=50] uncontrolled diabetics. DM was diagnosed according to American Diabetes Association. Permission was taken from ethics review committee of institute. Only willing subjects were included after they signed consent proforma voluntarily. Blood pressure, BMI, Blood glucose, Platelet counts, MPV and HbA1c were determined Data was typed on Microsoft excel, and then pasted SPSS 22.0 sheet for statistical analysis. Chi square test, one way ANOV, post-Hoc Tukey Cramer and Pearson's association was used for analysis of data variables. All data was analyzed at Confidence interval of 95% [
Results: MPV was raised in Diabetics in particular with uncontrolled glycemic index as shown in table II. MPV showed negative correlation with platelets was found with MPV [r = -0.27, p=0.03]. MPV was positively correlated with glycated HbA1 [r = 0.78, p= 0.0001]. HbA1c as high as 14.3% was noted in uncontrolled diabetics
Conclusion: The present study reports raised Mean platelet volume in Diabetics in particular uncontrolled diabetics. MPV showed positive correlation with HbA1c and negative correlation with platelet count
ABSTRACT
Objective: The present prospective study was conducted to observe the physiological effects of brisk walk on the systemic blood pressure in hypertensive subjects
Study Design: Observational study
Place and Duration of Study: This study was conducted at Outpatient Department, NICVD-Jinnah Postgraduate Medical Center [JPMC] / Physiology department, BMSI, Karachi from December 2001 to May 2002
Materials and Methods: A sample of 30 diagnosed cases of mild uncomplicated systemic hypertension and 30 healthy controls were selected as per study criteria. Aerobic exercise was explained as of doing regular briskwalking of 30 minutes on alternate days for 60 days. Systolic blood pressure [SBP], diastolic BP [DBP], heart rate [HR] and respiratory rate [RR] were checked at baseline and after 60 days of aerobic exercise. Consent of subjects and approval of ethics committee of institute was observed. Data was analyzed on the SPSS 10.0. Continuous and categoricaldata wasanalyzedbystudent`st-testand Chisquaretestrespectivelyas95%confidenceinterval
Results: Baseline systolic BP, diastolic BP, HR and RR were raised in hypertensive subjects compared to controls [p=0.001]. After 60 days aerobic exercise, the systolic BP, diastolic BP, HR and RR were reduced in hypertensive subjects compared to controls [p >0.05]
Conclusion: The present study concludes that the aerobic exercise improves Systolic blood pressure [SBP], diastolic BP [DBP], heart rate [HR] and respiratory rate [RR] in hypertensive subjects
ABSTRACT
Objectives: This study was undertaken to observe the effects of aerobic exercise on lipid profile in newly diagnosed type 2 diabetic patients
Study Design: Observational study
Place and Duration of Study: This study was conducted at Physiology Department, JPMC Karachi from December 2001 to May 2002
Materials and Methods: 30 adult male subjects with uncomplicated type 2 diabetes were selected from diabetic clinic of JPMC, Karachi. 30 apparently healthy adult male subjects were selected from friends, students and staff members of BMSI, as control. The subjects belonging to diabetic groups were then briefed about exercise protocol, which consisted of a regular brisk walk of 30 minutes on alternate days per week for 60 days
Results: Base line Values of mean HDL-cholesterol serum cholesterol, serum total triglycerides, LDL-cholesterol, and mean fasting blood glucose were significantly different in diabetic group as compared to control group [P<0.001] After aerobic exercise, all the parameters except HDL-C were significantly decreased while HDL-C was significantly increased as compared to the pre-exercise values
Conclusion: Regular aerobic exercises improve blood glucose, TAG, LDLc and cholesterol and increases the HDLc in type 2 diabetic subjects has been concluded by the present study
ABSTRACT
114-male student of 1st year and 2nd year M.B.B.S [mean age 24 years], were subjected to mental stress of class test examination and the Hb percent and platelet count were analyzed. The results were compared with the results which were taking after resting period given to them. All the participants were healthy and the selection was based on their well being and consent. The mean and standard deviation of differences in between stress and rest observations for both, the Hb percent and platelet count were calculated. The results were evaluated for level of significance by 95 percent confidence interval and student's paired t-test. There was a significant increase in Hb percent [P<0.001] with 2.08 percent increment during stress and in platelet count [P<0.001] with 17.15 percent increment at the time of mental stress. Our findings were in agreement with most of workers but contradictory to some others who were of the view that the increments were due to the stress induced catecholamine only and were not depending on the type and nature of stress