ABSTRACT
Objective:To investigate changes in autonomic nervous system function in elderly coronary heart disease patients with hypertension.Methods:Clinical data of 186 patients with coronary heart disease(CHD)from January 2017 to January 2021 in our hospital were retrospectively collected.Patients were divided into the CHD group(n=93)and the CHD with hypertension group(n=93)according to whether they had hypertension.All subjects underwent 24-hour dynamic electrocardiogram, and differences in heart rate variability(HRV)were analyzed and compared between the groups.Results:Values from time-domain parameters for HRV included the standard deviation of the normal-to-normal R-R intervals( SDNN)[(77.4±15.1)ms vs.(114.6±25.9)ms, t=11.97, P<0.05], the standard deviation of sequential five-minute R-R interval means( SDANN)[(66.8±14.5)ms vs.(97.4±25.0)ms, t=10.21, P<0.05], the SDNN index[(34.1±11.4)ms vs.(51.9±18.0)ms, t=8.07, P<0.05], the root mean square successive difference( rMSSD)[(26.1±13.9)ms vs.(36.1±27.2)ms, t=3.18, P<0.05], and the percentage of successive normal interbeat intervals greater than 50 milliseconds(PNN50)[(5.0±6.4)% vs.(8.3±11.0)%, t=2.53, P<0.05], and were lower in the CHD with hypertension group than in the CHD group.Values from frequency-domain parameters for HRV included low frequency(LF)[(168.9±202.8)ms vs.(443.6±663.6)ms, t=3.78, P<0.05], high frequency(HF)[(203.3±202.5)ms vs.(499.5±1222.7)ms, t=2.28, P<0.05], and the LF/HF ratio(1.0±0.7 vs.1.3±0.8, t=3.18, P<0.05), and were lower in the CHD with hypertension group than in the CHD group. Conclusions:Impairment of cardiac autonomic nervous system function is more serious in elderly CHD patients with hypertension than in elderly CHD patients.Heart rate variability is a valuable clinical indicator and may be used for treatment targets in evaluating dysfunction of the autonomic nervous system in CHD patients with hypertension.
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Objective To investigate the association of rs579459 polymorphism in ABO gene with clinical severity of coronary heart disease (CHD) in Chinese Han population. Methods Based on the results of study on the association with CHD conducted by our team ,the rs579459 polymorphism in ABO gene and clinical data of 515 Chinese Han patients with CHD and 908 healthy individuals were collected and analyzed with Plink 1.07 software. Results The rs579459 polymorphism in ABO gene using allele model showed a statistically significant difference between CHD and control group (OR :1.28 ,95％ CI :1.11-1.65 ;P=0.027).When stratified by the severity of CHD ,the rs579459 polymorphism in ABO gene using allele model showed statistically significant difference between the severe CHD group and control group (OR :1.78 ,95％ CI :1.25-2.34 ;P=1.85 × 10-4 ). Conclusions The rs579459 polymorphism of ABO gene is associated with susceptibility to CHD in Chinese Han population ,and also with the severity of CHD.
ABSTRACT
The Montreal Cognitive Assessment (MoCA) scale is a rating scale for rapid screening of mild cognitive impairment.In recent years,with the deepening of clinical research,the application scope of MoCA has been gradually expanded to the assessment of cognitive impairment-related diseases.This article reviews the clinical advances in research on MoCA in early screening of vascular cognitive impairment-no dementia