ABSTRACT
OBJECTIVE: The umbilical cord consists of two arteries and one vein and it functions in the transport between the maternal and fetal circulation. Biochemical analysis of fetal cord blood (FCB) during delivery could be beneficial in terms of understanding the fetal environment. In this study, we aimed to investigate oxidative parameters like malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels in FCB during delivery. METHODS: We collected FCB samples during caesarean section. Our study included 33 depressed mothers and 37 healthy controls. We investigated MDA, SOD, and CAT levels in FCB samples. RESULTS: We found no significant difference between groups in terms of MDA (p=0.625), SOD (p=0.940), and CAT (p=0.413) levels. CONCLUSION: Our study reveals probable protective effects of the placenta from oxidative stress. Future studies should include larger samples.
Subject(s)
Animals , Cats , Female , Humans , Pregnancy , Arteries , Catalase , Cesarean Section , Depression , Fetal Blood , Malondialdehyde , Mothers , Oxidative Stress , Placenta , Superoxide Dismutase , Superoxides , Umbilical Cord , VeinsABSTRACT
Repeated in vitro Fertilization [IVF] failure together with Ovarian Hyperstimulation Syndrome [OHSS] is one of the distressing situations leading couples to search for alternative treatment options. For such patients with Polycystic Ovarian Syndrome [PCOS] who have experienced Ovarian Hyperstimulation Syndrome, mild ovarian stimulation with in vitro oocyte maturation could be a promising alternative. Testicular Sperm Aspiration [TESA] of spermatozoa from a known obstructive azoospermic patient is a limiting factor for IVM [in vitro maturation] but the couple reported here accepted mild IVF -IVM with TESA. In the treatment of a 32-year old woman, 9 immature oocytes were retrieved, 5 in vitro matured oocytes [maturation rate 55%] and after fertilization by Intracytoplasmic Sperm Injection [ICSI], 3 oocytes [fertilization rate 60%] which had two pronuclei and two good quality embryos on day 2, were transferred. A live pregnancy was observed by ultrasound scan and healthy infant was delivered. Although the number of births from ICSI of immature oocytes injected with surgically derived sperm is quite low, the selection of this mode of therapy as an alternative to conventional IVF will overcome the limitations and provides a new option in IVF practice