Synthesis and Cell Line Activity of Angular Benzofuro Fused Naphthyridines.

The present work describes the preparation of novel compounds based on the structure of 2- substituted benzo[b]-furo[2,3-h][1,6]napthyridin-5[4H]-one (10). Their methyl and methoxy derivatives were synthesized and their cytotoxicity evaluated against a cancer cell line HeLa. The analogue bearing methyl group on the system is three times more potent than the methoxy group. One could suggest that the methyl group activates the inhibitor’s site. These results provide new information on the structure activity relationship of these naphthyridine based systems.