ABSTRACT
Objectives: Aim was to evaluate clinicopathological and treatment outcomes of diffuse sclerosing variant papillary thyroid carcinoma [DSV-PTC]. Design: Retrospective study. Setting: Two major tertiary care hospitals of Riyadh, Saudi Arabia
Material: Medical records of 1192 patients with confirmed papillary thyroid cancers [PTC], who were treated or followed up during the period of July 2000 and December 2012 were reviewed. Main outcome measure: To evaluate the clinicopathologic features and treatment outcomes of patients with DSV- PTC and perform comparative analysis of DSV-PTC with classic-variant PTC [CV-PTC]
Results: A total of 44 cases [3.7%] of DSV-PTC were identified. DSV-PTC patients were younger than their CV-PTC [p = 0.001]. The mean tumor size was larger in DSV-PTC as compared to CV-PTC [p < 0.0001]. Advanced pathologic tumor [pT] stage and positive lymph nodes were more often present in DSV-PTC than in CV-PTC [p < 0.0001 and p < 0.0001 respectively]. Median follow-up was 8.05 years [range: 1.62-11.4]. Ten-year disease-specific survival [DSS] rates were lower in DSV-PTC [74.4%] than in CV-PTC [89.4%]; p = 0.001
Conclusion: DSV-PTC is more aggressive variant as compared to CV-PTC, and is associated with inferior DSS rates. An aggressive surgical approach followed by radioiodine therapy is warranted for these patients
ABSTRACT
Renal cell carcinoma [RCC] has diverse behaviour. At the time of diagnosis, many patients are found to have metastases. Bones, lungs, liver and brain are the frequent homing sites of metastases. Parotid gland metastasis is the rarest manifestation of RCC. Here-in we report a case of a 70 year old Saudi male who underwent radical left nephrectomy in February 1997 for renal cell carcinoma [RCC] pT2N0M0. After remaining asymptomatic for 15 years, in January 2012, he presented with four months history of left cheek mass. Subsequent computed tomography [CT] and CT- positron emission tomography [PET] imaging showed left parotid lesion of size 1.3 cm. Patient underwent left parotidectomy. Histopathology was consistent with metastatic RCC. At nine months after metastatectomy, patient was doing well without any disease recurrence
ABSTRACT
Metastasis to the head and neck region from primary is rarest manifestation. Lung and breast carcinomas are the commonest malignancies to metastasize to the head and neck region. Oesophageal adenocarcinoma with metastasis to the oral cavity is a rarest presentation and is associated with dismal prognosis. Only few related case reports have been published so far. Her-in we report a case of 55 years old male who underwent radical oesophagectomy for adenocarcinoma of lower oesophagus twelve months back, now presented with hard mass in the right margin of tongue which was suspected as primary tongue carcinoma; subsequently was confirmed as metastatic oesophageal adenocarcinoma following excision. Two months after tongue excision, patient died of progressive metastatic disease
ABSTRACT
A Thyroglossal duct cyst [TGDC] is the most frequent congenital cervical anomaly [70% in children and 7% in adults] in the development of the thyroid gland. However, incidence of carcinoma arising from a TGDC is extremely rare [
ABSTRACT
Skin and subcutaneous metastases are uncommon, and mostly originating from cancers of the breast, kidney, colon, lung, and melanoma. Oesophageal cancers rarely metastasise to the skin and subcutaneous soft tissue. Skin and subcutaneous metastases are associated with dismal prognosis. Only few related case reports have been published so far. In this report, we describe a 52 year old patient with lower oesophageal adenocarcinoma who developed subcutaneous metastasis, 9 months after neoadjuvant che-moradiation followed by trans-hiatal esophagectomy