ABSTRACT
Objective: Objective of this study was to find out association between histopathology of oral carcinomas and addictive risk factors
Study Design: Observational / descriptive study
Place and Duration of Study: This study was conducted at Dental OPD, Liaquat University Medical Hospital and department of Pathology LUMHS Jamshoro/ Hyderabad from 2015 to 2016
Materials and Methods: Total 60 patients were included in the study having oral carcinomas. Careful clinical assessment following by complete medical history along with clinical examination was carried out. All the addictive cases were selected. All the information of various parameters like age, gender of patient, relevant clinical history, tobacco habit, other addictive associated risk factor, and microscopic histopathological findings of tissue specimen were carried out. All the addictive risk factor's association was noted with types of oral carcinoma
Results: Out of these 60 patients, maximum number of patients i.e. 29 [48.33%] were from > 50 years of age group. Majority of patients 35[58.33%] were illiterate while only 6[10%] were graduate. Majority of patients 21[35%] had carcinoma in buccal mucosa. Majority of the cases 46.66% multiple addictive habits, while only tobacco chewing, betal nut/manpuri, gutka, naswar and tobacco smoking habits were found with percentage of 8.34%, 10%, 8.34%, 6.66% and 20% respectively. According to histopathological findings squamous cell carcinoma was the most common in 85% of the cases, following by verrucous carcinoma in 6.67%, Micro-invasive SCC was only in 1 patient and other non-squamous cell carcinomas were found in 6.67% of the cases.On the association between histological findings and addictive risk factors no significant difference was found between squamous cell carcinoma and addictive risk factors p value 0.112, while VC, MISCC and other non-squamous cell carcinoma were significantly associated with patients having multiple addictive habits p value 0.02
Conclusion: We concluded that multiple mix addictions of tobacco chewing and smoking, gutka, naswar andbetal nuts are significantly associated with oral carcinomaand potentially increases the chances of oral malignancy in certain pre malignant conditions
ABSTRACT
To see the effectiveness of Proton Pump Inhibitors in patients with chronic cough at Liaquat UniversityHospital. Observational study. This study was conducted at ENT Department, Liaquat University Hospital, Jamshoro/Hyderabad from November 2010 to October 2011. Irrespective of age and gender 109 cases were recorded with history of chronic cough. After getting a detailed History all the cases were examined thoroughly for any pathology in Nose, Nasopharynx,Sinuses, Throat and Larynx in ENT department and then Sent to Physician to find or exclude the pathology in chest and Gastro intestinal tract. Required investigations were carried out in selected cases. All the cases after diagnosis were selected for PPI treatment for 30 days. Patient's response to the treatment was recorded. All the data regarding sign symptoms, clinical diagnosis, duration of cough and response of the cases to PPI treatment was entered on Performa for analysis. 109 cases were chosen in present study with chronic cough, majority of the cases 55 [50.45%] were found with age group of 41-60 years. Female were found in the big percentage 63 [57.79%], as compare to male 46 [42.20%], mostly 86[78.89%] cases had duration of cough under VIII weeks. 39 [35.77%] cases were noted with feeling of lump in throat and this was commonest symptom. 57 [52.29%] patients were found with complete response, 35 [32.11%] patients were noted with partial response and continued for some more days, while 17 [15.59%] patients had not respond to PPI treatment and those were advised some other investigations and treatment. PPI having prime role in cases of chronic cough. PPI can easily be given on Clinical ground even without more investigations
Subject(s)
Humans , Male , Middle Aged , Female , Adult , Cough , Chronic DiseaseABSTRACT
To determine the prevalence of fungal infection in the patients having nasal polyps at Liaquat University Hospital, Hyderabad. Observational and prospective study. This study was conducted in the Department of the ENT of Liaquat University Hospital, Jamshoro/Hyderabad from March 2012 to August 2012. Total 50 had selected. All the cases with nasal polyp, both genders and above 18 years of the age were integrated. Routine lab investigations had completed. Radiological examination including the X-ray of paranasal sinuses and CT scan had done to diagnosis sinuses, bony erosion, orbital and intracranial extension. Surgical procedure had done according to the need of the patient. After surgery all the samples separated in 2 places under sterile process. One for histopathology and 2[nd] in the normal saline had sent for fungal Culture of specimen. Total 50 cases were selected in the study after diagnosis of nasal polyp, mean age of the cases was mean +SD=36.05+7.21 years, male had found in the majority 31[62.0%]. Nasal obstruction was the most common 42 [84.0%] in the clinical presentation. Majority of the cases 26.0% were under went surgical procedure of nasal polypectomy. After done histopathology frequently diagnosis found as Inflammatory polyp 43 [86.0%], while08 [16.0%] cases were found with fungal infection and 42 [84.0%] were without fungal infection after culture test. In conclusion fungal infection is found most common in the cases having nasal polyps