ABSTRACT
Background: Lipoxin A4 is a potent anti- inflammatory and serval lipoxin forming multicellular interactions occur during strenuous exercise
Aim of the study: To evaluate diagnostic value of lipoxin A4 as a biomaker of exercise induced asthma
Subjects and Methods: This cross sectional study was conducted on forty- five asthmatic children divided in two groups ; EIA group: 25 children with history of exercise- induced symptoms of asthma confirmed by spirometry, Non EIA group: 20 patients who did not have history of exercise induced symptoms of asthma. Forty- five apparently healthy children were included as a control group with no history of asthma or atopic conditions. Their age and sex were matched with the patients group . For all patients, pulmonary fnction tests were done before and after a free rning test using portable spiromometery . Serum levels of lipoxin A4 were estimated for patients [after exercise] and controls using ELISA
Results: A significant difference was detected between the levels of lipoxin A4 in EIA and control grops [p vale 0.000]. there was significant differece between Non EIA patients ; however, the difference was statistically [p value 0.973]
Conclusion: Lipoxin A4 is a promising anti-inflammaory factor in management of asthma. it correlates with degree of reduction in FEV1in EIA. future pharmaceutical studies should consider lipoxin as a new therapeutic treatment in EIA