Large cell carcinoma with adenocarcinoma in lung

Large cell neuroendocrine carcinoma [LCNC] is a rare and aggressive cancer accounting for 3% of all lung cancers. A small percentage of LCNC called combined LCNC, can be seen in combinations with other lung tumor types. Multimodal therapy is proposed for this type of tumor but there is no any significant therapy since it is very rare tumor. This patient was a 66-year male and a heavy smoker with no symptoms of lung disease. Computed tomography core biopsy showed suspected adenocarcinoma. Right lower lobectomy was performed with mediastinal lymph node dissection via mini thoracotomy. The tumor was diagnosed as combined LCNC with adenocarcinoma. The patient was discharged on the seventh postoperative day and sent to the oncology clinic for chemotherapy. There has been no recurrence for eight months after surgery

Successful treatment of a late diagnosed esophageal perforation with mediastinitis and pericardial abscess

We herein report a case of late diagnosed thoracic esophageal perforation. A 60-year-old man was diagnosed as an esophageal perforation with mediastinitis and pericardial abscess by detailed history taking, chest computed tomography, esophagoscopy and inflammatory findings in his blood test. Surgical drainage of mediastinum and pericardium was able to effectively control infectious process and pericardial fibrosis. Endoscopic esophageal stent placement on the thoracicesophageal fistula promoted healing of the esophageal wall defect and enabled him to restart oral intake. This case report suggests that detailed history taking is important for all patients. Effective drainage of mediastinum and the use of esophageal stent may be the treatment options for late-diagnosed esophageal perforation