Increased resistin levels in intra-abdominal sepsis correlation with proinflammatory cytokines and acute physiology and chronic health evaluation [apache] II scores

Resistin, a hormone secreted from adipocytes and considered to be a likely cause of insulin resistance, has recently been accepted as a proinflammatory cytokine. This study aimed to determine the correlation between resistin levels in patients with intra-abdominal sepsis and mortality. Of 45 patients with intra-abdominal sepsis, a total of 35 adult patients were included in the study. This study was undertaken from December 2011 to December 2012 and included patients who had no history of diabetes mellitus and who were admitted to the general surgery intensive care units of Gazi University and Bulent Ecevit University School of Medicine, Turkey. Evaluations were performed on 12 patients with sepsis, 10 patients with severe sepsis, 13 patients with septic shock and 15 healthy controls. The patients' plasma resistin, interleukin-6 [IL-6], tumour necrosis factor alpha [TNF-alpha], interleukin-1 beta [IL-1beta], procalcitonin, lactate and glucose levels and Acute Physiology and Chronic Health Evaluation [APACHE] II scores were studied daily for the first five days after admission. A correlation analysis of serum resistin levels with cytokine levels and APACHE II scores was performed. Results: Serum resistin levels in patients with sepsis were significantly higher than in the healthy controls [P <0.001]. A significant correlation was found between serum resistin levels and APACHE II scores, serum IL-6, IL-beta3, TNF-alpha, procalcitonin, lactate and glucose levels. Furthermore, a significant correlation was found between serum resistin levels and all-cause mortality [P = 0.02]. The levels of resistin were significantly positively correlated with the severity of disease and were a possible mediator of a prolonged inflammatory state in patients with intra-abdominal sepsis

Primary Neuroendocrine Carcinoma in the Breast: A Case Report / 한국유방암학회지

Primary neuroendocrine carcinoma of the breast is an extremely rare neoplasm that differs from other types of breast carcinoma according to the pathological features. We describe here a case of primary neuroendocrine carcinoma in a 72-year-old woman who complainted of a lump in her left breast. After examination and evaluation, the diagnosis was made by a core needle biopsy and the subsequent immunohistochemical examination of the specimen revealed more detailed information. We performed modified radical mastectomy, which showed no axillary node involvement. The patient was given neither radiation nor chemotherapy, however, but hormonotherapy was started postoperatively. Any recurrence has not been demonstrated at 12 months after the operation.

Primary Neuroendocrine Carcinoma in the Breast: A Case Report / 한국유방암학회지

Primary neuroendocrine carcinoma of the breast is an extremely rare neoplasm that differs from other types of breast carcinoma according to the pathological features. We describe here a case of primary neuroendocrine carcinoma in a 72-year-old woman who complainted of a lump in her left breast. After examination and evaluation, the diagnosis was made by a core needle biopsy and the subsequent immunohistochemical examination of the specimen revealed more detailed information. We performed modified radical mastectomy, which showed no axillary node involvement. The patient was given neither radiation nor chemotherapy, however, but hormonotherapy was started postoperatively. Any recurrence has not been demonstrated at 12 months after the operation.