ABSTRACT
BACKGROUND: Familial benign chronic pemphigus is a rare autosomal dominant disorder characterized by persistently recurrent bullous and vesicular dermatitis of the sides of the neck, axillae, and apposing surfaces. Hailey and Hailey, Montes, and other some investigators reported the presence of bacteria in the lesions of familial benign chronic pemphigus, and suggested that bacteria was associated in the its pathogenesis. OBJECTIVE: The purpose of this study was to elucidate the association of bacteria in thepathogenesis of familial benign chronic pemphigus. METHODS: We performed Brown & Brenn Gram stain in 14 biopsy tissues, bacterial culture and sensitivity test in 10 cases, and decided the effective treatment methods in each case. RESULTS: 1. Man to woman ratio was 3.67: 1 and about 60% of patients were in their third and forth decades. The family history was found in 6 out of 14 cases(42.9%). 2. The lesions were predomiriantly distributed on the groins(85.7%), axillae(71.4%), neck(64.3 %), trunk(50.5%), antecubital fossa(214%). 3. In Brown & Brenn gram stain, the bacterial colonies in the stratum corneum were found in 12(85.7% ) out of 14 biopsy tissues. The cells and its keratohyaline granule in granular layer had blue or nealy black color in 13(92.9%) out of 14 cases. 4. In bacterial culture and sensitivity test, Staphylococcus aureus was identified in 7 cases(70.0 %), Staphylococcus hemolyticus, 2 cases(20.0%) and Streptococcus species, 1 case(10.0%). 5. The number of cases which showed effective response to antibiotics therapy was 8 (57.1%) out of 14 cases. CONCLUSION: These results suggest that bacteria or its toxin play a part of role in the production of lesions of familial benign chronic pemphigus and recurrent bacterial infection may cause recurring of this disease in the genetically predisposed persons.
Subject(s)
Female , Humans , Anti-Bacterial Agents , Axilla , Bacteria , Bacterial Infections , Biopsy , Dermatitis , Neck , Pemphigus, Benign Familial , Research Personnel , Staphylococcus , Staphylococcus aureus , StreptococcusABSTRACT
BACKGROUND: The incidence of cutaneous squamous cell carcinoma(SCC) has been increasing, but no analysis of the causative diseases of cutaneous SCC has been performed. OBJECTIVE: The purpose of this study was to investigate the causative disease of SCC. METHODS: Eighty-seven patients with cutaneous SCC were retrospectively studied. RESULTS: The possible causative diseases of cutaneous SCC were actinic keratosis(18 csaes), Bowen's disease(17 cases), actinic cheilitis(8 cases), burn scar(4 cases), arsenical keratosis(3 cases), xeroderma pigmentosum(3 cases), chronic discoid lupus erythematosus(2 cases), epidermodysplasia verruciformis(2 cases), leukoplakia(1 case), chronic radiodermatitis(1 cases), erythroplasia of Queyrat (1 case), osteomyelitis sinus(1 case), lichen planus(1 case), porokeratosis of Mibelli(1 case), and the other 21 cases were of unknown origin. CONCLUSION: The causative diseases of cutaneous SCC were related to sun-exposure, and chronic dermatoses.
Subject(s)
Humans , Actins , Burns , Carcinoma, Squamous Cell , Erythroplasia , Ichthyosis , Incidence , Lichens , Osteomyelitis , Porokeratosis , Retrospective Studies , Skin DiseasesABSTRACT
BACKGROUND: The incidence of cutaneous squamous cell carcinoma(SCC) has been increasing, but no analysis of the causative diseases of cutaneous SCC has been performed. OBJECTIVE: The purpose of this study was to investigate the causative disease of SCC. METHODS: Eighty-seven patients with cutaneous SCC were retrospectively studied. RESULTS: The possible causative diseases of cutaneous SCC were actinic keratosis(18 csaes), Bowen's disease(17 cases), actinic cheilitis(8 cases), burn scar(4 cases), arsenical keratosis(3 cases), xeroderma pigmentosum(3 cases), chronic discoid lupus erythematosus(2 cases), epidermodysplasia verruciformis(2 cases), leukoplakia(1 case), chronic radiodermatitis(1 cases), erythroplasia of Queyrat (1 case), osteomyelitis sinus(1 case), lichen planus(1 case), porokeratosis of Mibelli(1 case), and the other 21 cases were of unknown origin. CONCLUSION: The causative diseases of cutaneous SCC were related to sun-exposure, and chronic dermatoses.
Subject(s)
Humans , Actins , Burns , Carcinoma, Squamous Cell , Erythroplasia , Ichthyosis , Incidence , Lichens , Osteomyelitis , Porokeratosis , Retrospective Studies , Skin DiseasesABSTRACT
Hypergammaglobulinemic purpura of Waldenstrom is characterized by recurrent episodes of petechiae, hypergammaglobulinemia, an elevated erythrocyte sedimentation rate, and the presence of rheumatoid factor, and leukocytoclastic vasculitis or mild lymphocytic perivasculitis. There is a primary type and a secondary type which is associated with other autoimmune diseases. We present a csae of a 48 year-old female with hypergammaglobulinemic purpura of Waldenstrom. She showed characteristic clinical, histopathological and laboratory findings consistent with hypergammaglobulinema purpura of Waldenstrom. Although there was a decrease in the Schimer test, we couldt den ostrate an association with Sjogrens syndrome. We think that this case may be a secondary type and needs a follow-up study.
Subject(s)
Female , Humans , Middle Aged , Autoimmune Diseases , Blood Sedimentation , Follow-Up Studies , Hypergammaglobulinemia , Purpura , Purpura, Hyperglobulinemic , Rheumatoid Factor , Sjogren's Syndrome , VasculitisABSTRACT
A case report of a 60 year-old man with lichen aureus of leg is presented. Clinically the solitary golden to purple colored patch consists of lichenoid papules, plsque, and mild petechiae around the lesion, and the histology reveals a dense and bandlike infiltrate hugging thepidermis. It consists of lymphocytes, histiocytes, eosinophils, and many extravasated erythrocytes and hemosiderin in dermis, but a few red cells and increased melanin pigment can also be seen in the epidermis. The eruption is mildly itchy and has been present 6 months.