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1.
Journal of Korean Neuropsychiatric Association ; : 32-40, 2005.
Article in Korean | WPRIM | ID: wpr-139126

ABSTRACT

OBJECTIVES: Recent genetic studies have suggested a preferential transmission of the Dopamine D5 receptor gene (DRD5) 148bp marker allele. The aim of this study is to test the association between DRD5 and ADHD. METHODS: 106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test (TDT) and haplotype-based haplotype relative risk test (HHRR). And also the ADHD children were compared with 212 age and gender matched normal controls. RESULTS: We found the evidence for an association of short alleles of DRD5 dinucleotide repeat polymorphism in both case control and family based studyies. Additionally, we observed some evidence for biased transmission of allele 152 bp and 144 bp. CONCLUSION: Our results lend credence to the notion that the relationship between ADHD and DRD5 is complex. The number of cases and informative transmissions in our study were small, therefore it would be premature to make any conclusions concerning the role of DRD5 in ADHD. Further work is needed to support these findings.


Subject(s)
Child , Humans , Alleles , Attention Deficit Disorder with Hyperactivity , Bias , Case-Control Studies , Dinucleotide Repeats , Dopamine , Haplotypes , Parents , Receptors, Dopamine D5
2.
Journal of Korean Neuropsychiatric Association ; : 32-40, 2005.
Article in Korean | WPRIM | ID: wpr-139123

ABSTRACT

OBJECTIVES: Recent genetic studies have suggested a preferential transmission of the Dopamine D5 receptor gene (DRD5) 148bp marker allele. The aim of this study is to test the association between DRD5 and ADHD. METHODS: 106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test (TDT) and haplotype-based haplotype relative risk test (HHRR). And also the ADHD children were compared with 212 age and gender matched normal controls. RESULTS: We found the evidence for an association of short alleles of DRD5 dinucleotide repeat polymorphism in both case control and family based studyies. Additionally, we observed some evidence for biased transmission of allele 152 bp and 144 bp. CONCLUSION: Our results lend credence to the notion that the relationship between ADHD and DRD5 is complex. The number of cases and informative transmissions in our study were small, therefore it would be premature to make any conclusions concerning the role of DRD5 in ADHD. Further work is needed to support these findings.


Subject(s)
Child , Humans , Alleles , Attention Deficit Disorder with Hyperactivity , Bias , Case-Control Studies , Dinucleotide Repeats , Dopamine , Haplotypes , Parents , Receptors, Dopamine D5
3.
Journal of the Korean Society of Biological Psychiatry ; : 146-154, 2004.
Article in Korean | WPRIM | ID: wpr-725268

ABSTRACT

OBJECTIVE: Attention deficit hyperactivity disorder(ADHD) is the most common childhood psychiatric disorder, affecting 3-5% of school-aged children. Although the biological basis of ADHD is unknown, family studies provide strong evidence that ADHD has a genetic basis. Recent genetic studies have suggested associations between ADHD and serotonin 1B(5HT1B) receptor gene G861C polymorphism. The aim of this study is to test for the association between ADHD and 5HT1B receptor gene G861C polymorphism in Korean population. METHOD: We processed DNA extraction and genotyping. 106 Korean children with ADHD and their parents were analyzed using the transmission disequilibrium test(TDT) and haplotype-based haplotype relative risk (HHRR). And the ADHD children were compared with 212 age and gender matched normal controls. RESULTS: There was no statistical difference of distributions between ADHD cases and controls. We did not observe any preferential transmission of alleles of 5HT1B receptor gene G861C polymorphism in ADHD. CONCLUSIONS: Though there is the possibility of failing to detect small genetic effects, our results show no evidence of an association between ADHD and 5HT1B receptor gene G861C polymorphism in the Korean population and indicate that it is unlikely that the 5HT1B receptor is implicated in the susceptibility to ADHD.


Subject(s)
Child , Humans , Alleles , Attention Deficit Disorder with Hyperactivity , Case-Control Studies , DNA , Haplotypes , Parents , Receptor, Serotonin, 5-HT1B , Serotonin
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