ABSTRACT
Multiple Sclerosis is one of the most common and disabling neurological disease. Recent studies reported the possible role of serum uric acid in the pathogenesis of multiple sclerosis. This study was done to examine the role of serum uric acid in patients with multiple sclerosis. This case - control study was carried out on 70 multiple sclerosis patients as cases and 70 healthy subjects as controls in teaching hospital in Rafsanjan, Iran during 2010. The two groups were matched in age and gender. The serum uric acid level of subjects in case and control groups was measured by enzymatic colorimetric method. Data were analyzed using SPSS-17 and student t-test. The mean serum uric acid level in cases and controls was 3.871 +/- 1.193 mg/dl and 4.171 +/- 1.39 mg/dl, respectively, this difference was not significant. Also, there was not significant relationship between serum uric acid level and gender in multiple sclerosis patients. This study indicated that the serum uric acid level is not changed in multiple sclerosis patients compared to controls
Subject(s)
Humans , Male , Female , Multiple Sclerosis , Case-Control StudiesABSTRACT
fibrinolytic agents like streptokinase [SK] and urokinase [UK] are urgent treatment of thromboembolism. Besides thrombolysis, these medications have side effect like: generalized lytic state, serum fibrinogen decrease, effect on body hemostasis and life threatening bleedings, allergic reaction and urticaria. Studies have shown that some patients don't response to SK, for example patients that have used SK one or two times or patients with streptococcal disease. In this study, we studied the fibrinolytic activity of Amirkabiria odoratissima mozaffarian to find the natural compounds that can be used in treatment of thromboembolism. Polyphenolic extract and the essential oil were prepared. Then essential oil was analyzed by G C. Mass. Fibrinolytic effects of SK [as positive control and comparison], extract and essential oil of Amirkabiria odoratissima mozaffarian was studied by flourimetric method.At first fibrinogen was labeled with FITC [Flourescein Isothiocyanate] and then labeled thrombus was produced in plasma with calcium ion. Then SK [100-1000 unit/ml] and essential oil at V/V dilutions of [1/1, 1/10, 1/100, 1/1000] and extract [1/1, 1/10, 1/100, 1/1000] was added and after 15, 30, 60 min, fluorescence was measured. Results showed linear relationship between fluorescence and SK concentration between 300-700 unit/?l. Essential oil of Amirkabiria odoratissima mozaffarian was effective in thrombolytic agent. Results has shown that Amirkabiria odoratissima mozaffarian extract has considerable fibrinolytic effects. So, study of different fractions of this plant extract and isolation and purification of the active fibrinolytic component is recommended