ABSTRACT
The chromogenic reagent p-dimethylaminocinnam aldehyde [PDAC] is introduced for the determination of the antidiabetic drug gliclazide by two different colorimetric methods. The first method is based on measurement of the color produced by heating gliclazide and PDAC for 45 minutes at 70C. The second method involves measurements of the color developed as a result of the reaction between the hydrolysis product of gliclazide, N-aminocyclopentanopyrrolidone and PDAC with the formation of red Schiff's base. The color developed obey Beer's law in the concentration range 20-60 Ug/ml in the first method and 100-250 Ug/ml in the second. When the proposed methods were applied for the determination of gliclazide added to diamicron tablets, recoveries were 100.5-100.83 and 100.52-101.06%