Effect of eicosapentaenoic acid [EPA] and vitamin e on the blood levels of inflammatory markers, antioxidant enzymes, and lipid peroxidation in iranian basketball players

Exercise can change the release of numerous cytokines and modulate their receptor systems. Dietary w-3 lipids may decrease the levels of inflammatory cytokines and prostaglandins [PGs]. Therefore, in this study, we investigated the effects of exercise and eicosapentaenoic acid [EPA] supplementation, with or without vitamin E, on the blood levels of IL-2, TNF-alpha catalase, glutathione reductase, and MDA in male basketball players. Thirty-four well-trained male basketball players were enrolled into the study. Venous blood samples were obtained from all subjects between 5:00 and 6:00 p.m., after intensive endurance exercising for 2 hours, at the baseline and after intervention. Subjects received 2g EPA and/or 400 IU vitamin E or placebo depends on their groups for 6 weeks. There were significant fall [paired /-test] in TNF-a in groupl [P< 0.05], and in MDA in group 3 [P<0.05], whereas there were significant increase in glutathione reductase in groups 1 and 3 [P< 0.05], and in MDA in group2 [P< 0.05].There were significant differences [Tukey] in glutathione reductase between groups 2 and 3 [P< 0.05], and in IL-2 between groups 1 and other groups [P< 0.01], but there were no significant differences in MDA, CAT, and TNF-a, among groups after 6 week of intervention. Six weeks of EPA+vitamin E supplementation enhances the plasma levels of IL-2 and erythrocytes glutathione reductase, whereas it reduces TNF-alpha, and 6 weeks of EPA supplementation alone enhances only the serum level of MDA

[Treatment results in hydrofluoric acid burns]

Background: Hydrofluoric acid and other fluorine compounds are used in different industries worldwide. Fluoride ion bonding with Calcium and Magnesium ions interferes with cell enzymatic systems and causes cell death. Any hesitation in diagnosis and treatment can lead to irreversible injuries in exposed individuals. Sectional study was conducted on 74 workers who had occupational

Material and Method: This cross exposure to Hydrofluoric acid. After dermal contamination, treatment procedures at the time of exposure and later in the medical center included decontamination with water, topical application of Calcium Gluconate Gel 2.5% and/or Benzalkonium Chloride solution. Workers and physicians were asked to fill in separate questionnaires providing data on the type and extent of burn and treatment procedures. Data were analyzed by descriptive and analytical methods in SPSS data bank

Results: 56 cases [75.7%] had carried out decontamination with water and 24 cases [32.4%] had applied Calcium Gluconate Gel immediately after exposure. In the clinic, treatment procedures included: decontamination for 46 cases [62.16%] and Calcium Gluconate Gel for 70 cases [94.59%]. More than 80% of burns were first degree at the time visited by physician and no complications observed in later follow-ups

Conclusion: It can be concluded that the initial washing with water and application of Calcium Gluconate Gel 2.5% at the time of exposure and later in the medical center is an effective and acceptable method in HF burn