ABSTRACT
The present work comprised the study of 50 cases besides 10 controls. The necessary clinical and laboratory investigations had been carried out for all subjects. In addition, PC was assayed. A significant prolongation of PT, APTT has been observed in all diabetic group as compared to the control group. Insignificant decrease in fibrinogen level has been observed in all diabetic group as compared to control group. Insignificant increase in PC activity has been observed in all diabetic group as compared to control group. This may be an attempt by the body to overcome hypercoagulability [Vigano et al. 1984]. Significant decrease in PC activity has been observed in diabetic bilharzial group as compared to the diabetic non bilharzial group
Subject(s)
Biomarkers , Fibrin , FibrinogenABSTRACT
The aim of this study is to assess the effect of calcium antagonists on left venticular and ventilatory functions in patients with ischaemic heart disease associated with obstructive lung disease. The material of this work comrised [10] healthy subject as a control group and [20] patients with symtomatizing ischaemic heart disease associated with obstructive airways diseases- as a test group, the test group was divided into two subgroups, one assigned for use of Verapamil [10] patients and the other for Nifedipine [10] patients. After taking detailed clinical history and parforming careful physical examination, all patients were subjected to, urine and stool analysis, fasting blood sugar X- ray film ECG, measurements of systolic time intervals [STIs] including [Q-S21], PEP1, LVET and PEP/ LVET ratio] and ventilatory function tests, including [FVC, FEV1 and FEV1/FVC%]. STIs and ventilatory parameters were done before and in the 10[th] day of using either Verapamil or Nifedipine. Comparative analysis of STIs in both subgroups assigned for use of either Verapamil or Nifedipine showed left ventricular dysfunction as shown from the significant prolongation of PEPI, shortening of LVET and rise in PEP/LVET ratio, also insignificant prolongation of Q-S21 was observed, indicating mild left ventricular dysfunction. On the other hand, comparing the same parameters of STIs after versus before use of either Verapamil or Nifedipine. Showed no significant prolongation of PEPI, shortening of LIVT1 or rise in PEP/LVET ratio. Comparative analysis of ventilatory parameters after versus before the use either Verapamil or Nifedipine Showed non-significant changs. It may be concluded, that left ventricular dysfunction is found in patients with ischaemic heart disease associated with obstructive airways disease, and the use of either Verapamil or Nifedipins drugs is safe in such patients, as they produces mild negative inotropy and left ventricular dysfunction which were short of significance and negligable in comparison to its benificial effect, on the other hand have no adverse or improving effect on ventilatory function in patients with chronic obstructive airway diseases