ABSTRACT
To examine whether dietary supplementation with omega-3 fatty acids from Clupeonella grimmi can relieve symptoms of dysmenorrhoea, we carried out a cross-over clinical trial on 36 girls aged 18-22 years. They were randomly allocated into 2 groups of 18. Group A received 15 mL fish oil daily [550 mg eicosapentaenoic acid; 205 mg decosahexaenoic acid] while Group B received placebo. After 3 months, the treatment regimens were swapped. The treatment groups reported a significant difference after 3 months of supplementation with fish oil [visual analogue scale score 20.9 compared with 61.8 for the placebo [P = 0.001]. There was also a marked reduction in low back pain and abdominal pain [P < 0.05], and participants needed significantly fewer rescue doses of ibuprofen while using fish oil