ABSTRACT
Introduction: Diabetes mellitus is associated with a wide range of kidney and liver disorders. The aim of this study was to compare the effect of alcoholic extract of aerial parts of Melissa officinalis on indicators of liver function and kidney in diabetic rats
Materials and Methods:Thirtyfive wistar rats were divided into 5 groups [n=7 each] as follows: Control, diabetic control and three diabetic groups, which received alcoholic extract of Melissa officinalis at doses of 100, 200 mg/kg body weight respectively through gastric gavage and glibenclamide 10 mg/ kg, for a period of 3 weeks. Diabetes was induced by streptozotocin [STZ]. At the end of this period [21 days], blood samples were collected for measurement of liver enzymes and factors for data analysis
Results: Amounts of enzyme levels of alanine transaminase [ALT] and aspartate aminotransferase [AST] in the group treated with the extract, compared to the diabetic control group showed no significant changes, whereas serum levels of alkaline phosphatase [ALP] and gamma glutamyl transferase [GGT] were significantly reduced [P<0.05], which declined most in the group receiving the minimum dose of the extract. Serum creatinine and urea in the group receiving the highest dose showed a significant decrease compared to other groups [P<0.05]
Conclusion: The extract Melissa officinalis with lower levels of liver enzymes, particularly ALP and GGT and renal markers, urea and creatinine was effective in improving liver function and treatment of diseases of the liver and kidneys
ABSTRACT
The People believe that herbal medicines are not toxic, but the toxicity of these drugs are reported to be seen. Therefore, the aim of this study was to evaluate hepatic and renal toxicity is Chelidonium majus hydroalcoholic extract. In this study, 35 male Wistar rats were divided into 5 groups [n=7], control group with normal diet and sham group with fat diet and experimental groups of animals hpercholesterolemia that received the minimum dose of 100, averaged 200 and maximum dose of 300 mg/kg hydroalcoholic extract Chelidonium majus [that collected from farms in the North of the country] by gavage. After this Period [21 days], blood samples were drawn and levels of liver alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline Phosphatase [ALP], albumin and total Protein as well as renal creatinine and blood urea nitrogen [BUN] were measured. The data obtained were analyzed using SPSS version 17. The ALT was not seen any significant changes between the groups treated with the extract. AST, albumin, total Protein and creatinine increased, but the amount of ALP decreased significantly in high dose of extract. BUN in groups receiving the at least extract dose was not any significant changes compared to the control group but Cholesterol had a decreased significant changes at same dose compared to the control group [p<0.05]. Since the amount of AST, albumin and creatinine extract the maximum dose is increased, especially at doses appear to extract Chelidonium majus have high toxic effects on the liver and kidneys