ABSTRACT
Herbal products consumption is increased worldwide. This study was done to compare the effect of Evening Primrose, Vitex agnus and vitamin E on premenstrual syndrome. In this clinical trials study, 210 women with premenstrual syndrome were randomly divided eqaly into Evening Primrose [500 mg, 3 times per day], Vitex agnus [40 mg/day] and vitamin E [400 Iu/day] groups. The subjects were received the thraputic regiment for 2 months. Severity of premenstrual syndrome was recorded for each subject using DSR Dickerson questinare, perior and at the end of intervention. After intervention, severity of premenstrual syndrome was reduced in Evening Primrose group [60.58 +/- 30.6 to 34.09 +/- 19.81], Vitex agnus [61.23 +/- 30.54 to 25.25 +/- 17.78] and the vitamin E group, [61.24 +/- 32.04 to 54.9 +/- 19.24]. Severity of premenstrual syndrome were reduced in the Evening Primrose and Vitex agnus groups in compared to vitamin E group [P<0.05]. Severity of premenstrual syndrome were reduced in Vitex agnus in comparision with Evening Primrose [P<0.05]. Vitex agnus, Evening Primrose and vitamin E can reduce severity of premenstrual syndrome, but therapeutic effect of Vitex agnus is more than Evening Primrose and vitamin E