ABSTRACT
Introduction: acid base disorders are considered as important but preventable problems in newborns
Objective: our purpose was to compare the effect of intrapartum 5% glucose in the intravenous fluid on umbilical cord acid-base and glucose status after spontaneous vaginal delivery
Materials and Methods: this research is a control- case and a prospective randomized trial. To conduct this study, 200 pregnant women presenting to obstetrics and Gynecology wards of hospitals affiliated to Shiraz University of Medical Sciences were selected. These parturients were at age range of 18-39, healthy, with cervical dilatation >/= 4cm[active phase] and vertex presentation with normal fetal heart rate. 100 women received ringer lactate solution and 100 women ringer's lactate solution containing 5% glucose as maintenance Iv fluid during labor. Blood gases of neonates were compared in both groups
Results: there was a significant difference in cord PH in R/L +5% glucoses as a maintenance Iv fluid between 100 parturients of case group [7.29+/- 0.03] and in R1L solution in 100 parturients of control group [7.22+/- 0.04 [p=0.00] and pco2 in R/L+5% glucose was lower than R1L group [48.7 mm Hg+/- 6.1 versus 57.7 mmHg+/-2.3 [p=0.00] and HCO3 in R/L+5% glucose was higher than R/L group [24.8 meq/L+/- 1.8 versus 20.9 meq/L+/-2.07 [p=0.00] and base excess in first group - 4.8+/-0.7 meq/L versus- 5.7+/-1 meq/L e p=0.00]. There were no statistical differences between two groups according to cord arterial glucose and neonatal glucose level and Apgar scores
Conclusion: intrapartum intravenous fluid consisting of lactate Ringer's solution containing 5% glucose reduces umbilical cord acidemia and hypercarbia and base excess but increased HCO3 and no change in cord level of glucose was observed. Lactated Ringer's solution containing 5% glucose maybe a preferable solution than solution without glucose as an intravenous fluid during labor