Does serum albumin level affect the healing outcomes of simple diaphyseal tibial fractures?

Aims: to quantify the serum albumin level and its correlation with fracture healing progression and outcomes in adult Patients

Settings and Design: a prospective cohort study at an institutional trauma center

Materials and Methods: a total of 50 adult patients with simple, fresh traumatic diaphyseal fractures of both bones of the leg managed conservatively were included in the study. Serum albumin was measured initially and at the 6[th] week postfracture. The clinico-radiological follow-up was done to analyze the fracture healing progression and their final outcomes, which were correlated with the quantified serum albumin level of the patients

Statistical Analysis Used: student t-test, Mann-Whitney U-test and Pearson correlation coefficient

Results: as per the last clinico-radiological follow-up at the 24[th] week, patients were grouped into two groups: Group I [normal union n = 38] and Group II [impaired healing n = 12]. The mean serum albumin levels were significantly higher in Group I when compared to Group II. The association between the serum albumin level at baseline and at the 6[th] week was moderate. The best cut-off measure of serum albumin level was 3.45 g/dL, both at baseline and at the 6[th] week after fracture to predict the healing outcome. The correlation of serum albumin levels with fracture healing outcomes was statistically significant

Conclusion: serum albumin is moderately associated with the baseline and 6[th]-week values and showed a positive correlation with the bony healing progression and may provide an early predictor of the healing outcomes of simple diaphyseal tibial fractures

Effect of yogic intervention on the autonomic nervous system in the patients with coronary artery disease:a randomized controlled trial

In this study 258 patients from the Department of Cardiology in Chhatrapati Shahuji Maharaj Medical University, Lucknow were selected to participate. All had been diagnosed with coronary artery disease. They were randomly divided into 2 groups, the yoga group and the non-yoga group, 129 in each group; 208 completed the study protocol. The yogic intervention consisted of 35-40 min/day, 5 days a week over a period of 18 months in the Department of Physiology. Autonomic function testing was done in both the groups at zero time and after 18 months. We observed a statistically significant reduction in body mass index, waist circumference, systolic and diastolic blood pressure, and heart rate [P < 0.05], i.e. a significant positive effect was observed when yoga therapy was used as an adjunct in patients with coronary artery disease

Physiological and Functional Evaluation of the Transposed Human Pylorus as a Distal Sphincter

BACKGROUND/AIMS: Studies evaluating the human pylorus as a sphincter are scanty and contradictory. Recently, we have shown technical feasibility of transposing the human pylorus for end-stage fecal incontinence. This unique cohort of patients provided us an opportunity to study the sphincter properties of the pylorus in its ectopic position. METHODS: Antro-pylorus transposition on end sigmoid colostomies (n = 3) and in the perineum (n = 15) was performed for various indications. Antro-pylorus was assessed functionally (digital examination, high resolution spatiotemporal manometry, barium retention studies and colonoscopy) and by imaging (doppler ultrasound, MRI and CT angiography) in its ectopic position. RESULTS: The median resting pressure of pylorus on colostomy was 30 mmHg (range 28-38). In benign group, median resting pressure in perineum was 12.5 mmHg (range 6-44) that increased to 21.5 mmHg (range 12-29) (P = 0.481) and 31 mmHg (range 16-77) (P = 0.034) on first and second follow-up, respectively. In malignant group, median post-operative pressures were 20 mmHg (range 14-36) and 21 mmHg (range 18-44) on first and second follow-up, respectively. A definite tone and gripping sensation were felt in all the patients on digital examination. On distal loopogram, performed through the diverting colostomies, barium was retained proximal to the neo-pyloric valve. Both perineal ultrasound and MRI showed viable transposed graft. CT angiography and color doppler studies confirmed vascular flow in the transposed position. CONCLUSIONS: The human pyloric valve can function as a tonic sphincter when removed from the gastroduodenal continuity.

Genotoxic effects of two commonly used food additives of boric acid and sunset yellow in root meristems of Trigonella foenum-graecumg

Food additives are the substances that are intentionally added to modify visual appearance, taste, texture, processing or the storage life of food. There has been significant controversy associated with the risks and benefits of food additives. The effect of different concentrations of food additives viz. boric acid and sunset yellow on the chromosomes of Trigonella foenum-graecum L. was investigated. Four concentrations of the two food additives [0.25, 0.50, 0.75 and 1%] were used for 3 hours. All concentrations of boric acid and sunset yellow showed mitoinhibitory effect in root tips of Trigonella foenum-graecum and increase in chromosomal aberrations. Various types of metaphasic and anaphasic aberrations were scored and it was found that metaphasic aberrations were more prominent than the anaphasic aberrations. The most observed aberrations induced by boric acid were stickiness at metaphase, bridges at anaphase, stickiness at anaphase, and scattering at metaphase, while the most prevalent aberrations caused by sunset yellow were precocious movement, unorientation at anaphase, scattering at metaphase and unorientation at metaphase. The result of present study clearly establishes the genotoxic behavior of boric acid and sunset yellow

Spontaneous rupture of a giant hepatic hemangioma- sequential management with transcatheter arterial embolization and resection

Hemangioma is the most common benign tumor of liver and is often asymptomatic. Spontaneous rupture is rare but has a catastrophic outcome if not promptly managed. Emergent hepatic resection has been the treatment of choice but has high operative mortality. Preoperative transcatheter arterial embolization [TAE] can significantly improve outcome in such patients. We report a case of spontaneous rupture of giant hepatic hemangioma that presented with abdominal pain and shock due to hemoperitoneum. Patient was successfully managed by TAE, followed by tumor resection. TAE is an effective procedure in symptomatic hemangiomas, and should be considered in such high risk patients prior to surgery

case-control study of bidi smoking and bronchogenic carcinoma

To evaluate the risks imposed by tobacco smoking, in particular, bidi smoking, in the development of lung cancer. Two hundred eighty-four histologically confirmed patients of bronchogenic carcinoma and 852 controls matched for age, sex, and socioeconomic status were interviewed according to a predesigned questionnaire. Effects of individual variables defining the various aspects of tobacco smoking, in particular, bidi smoking, were assessed using logistic regression models. 81.3% cases of bronchogenic carcinoma were ever smokers as compared with 42.2% among controls. The odd ratios for ever smoking, bidi smoking, and cigarette smoking were 5.9 [confidence interval [CI] 4.3, 8.4], 6.1 [CI 4.3, 8.7], and 5.3 [CI 2.7, 10.4], respectively. Bidi smoking poses a very high risk for lung cancer even more than that of cigarette smoking

Evaluation of inhibitory effect of the plant Phyllanthus amarus against dermatophytic fungi Microsporum gypseum / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>The antifungal activity of various solvent extracts (such as ether, chloroform, ethyl acetate and ethyl alcohol) of the plant Phyllanthus amarus against dermatophytic fungi Microsporum gypseum was observed.</p><p><b>METHOD</b>Antifungal bioassay in terms of reduction in weight, colony diameter and sporulation of the target fungal colony was carried out using Broth Dilution method. Results Root part of the plant, extracted in various organic solvents did not show any noticeable antifungal activity. The percentage inhibition observed in different solvent extracts of aerial part was found as reduction in weight: chloroform [50.3%], ethyl acetate [27.7%] and ethyl alcohol [12.1%], reduction in colony diameter: chloroform [53.4%], ethyl acetate [31.4%] and ethyl alcohol [15.0%] and reduction in sporulation: maximum inhibition in chloroform extract, at test concentration of 4000 ppm at incubation period of 8 days.</p><p><b>CONCLUSION</b>Chloroform fraction of the aerial part of the plant P. amarus shows significant inhibitory effect against dermatophytic fungi M. gypseum and requires chemical characterization for its bioactive principle.</p>