ABSTRACT
The objective of the present study is to develop and investigate the swelling behavior of pH-sensitive Superporous Hydrogel [SPH] and SPH composite [SPHC]. A novel superporous hydrogel containing poly [methacrylic acid-co-acrylamide] was synthesized from methacrylic acid and acrylamide through the aqueous solution polymerization, using N,N-methylenebisacrylamide as a crosslinker and ammonium persulfate as an initiator. SPHCs were made in the same way, except for the using of Ac-Di-Sol as a stabilizer. The synthesized SPH and SPHC were characterized by Fourier-transform infrared spectroscopy, swelling kinetics, porosity, mechanical properties and scanning electron microscopy. The swelling of SPH and SPHC was sensitive towards the pH, ionic strength, and temperature stimuli. The study of the surface morphology of SPH using scanning electron microscopy showed a highly porous structure. SPH polymers showed higher swelling ratio but less mechanical stability compared to SPHC polymers, which showed lower swelling ratio but a higher mechanical stability. With a change in pH from acidic to basic, a considerable increase in swelling was observed. Since the prepared SPH and SPHC swell only in the basic pH, it may be concluded that SPH and SPHC can be used as the pH-sensitive drug delivery system
ABSTRACT
Olanzapine is an antipsychotic used in treatment of schizophrenia. This research was carried out to design oral controlled release matrix pellets of water insoluble drug Olanzapine [OZ], using blend of Sodium Alginate [SA] and Glyceryl Palmito-Stearate [GPS] as matrix polymers, micro crystalline cellulose [MCC] as spheronizer enhancer and Sodium Lauryl Sulphate [SLS] as pore forming agent. OZ formulations were developed by the pelletization technique by drug loaded pellets and characterized with regard to the drug content, size distribution, Scanning Electron Microscopy [SEM], Differential Scanning Calorimetry [DSC], Fourier Transform Infrared Spectroscopy [FTIR] and X-ray Diffraction study [XRD]. Stability studies were carried out on the optimized formulation for a period of 90 days at 40 +/- 2°C and 75 +/- 5% relative humidity. The drug content was in the range of 93.34-98.12%. The mean particle size of the drug loaded pellets was in the range 1024 to 1087 micro m. SEM photographs and calculated sphericity factor confirmed that the prepared formulations were spherical in nature. The compatibility between drug and polymers in the drug loaded pellets was confirmed by DSC and FTIR studies. Stability studies indicated that pellets are stable. XRD patterns revealed the crystalline nature of the pure OZ. Loose surface crystal study indicated that crystalline OZ is present in all formulations and more clear in formulation F5. Drug release was controlled for more than 24 hrs and mechanism of the drug release followed by Fickian diffusion. It may be concluded that F5 is an ideal formulation for once a day administration