Kinetics of degradation of flucloxacillin in different solutions and in the presence of some intravenous components

The kinetics of degradation of flucloxacillin in solution was investigated at 37C, 70C, and constant ionic strength of O.5 over a pH range of 2-7. The decomposition followed a pseudo first order kinetics under the experimental conditions studied and the rates were found to be influenced by general acid base-catalysis. The apparent heats of activation were determined to be 20.72 kCal and 21.64 kCal at pH 4 and 6, respectively. The pH rate profile in buffer solutions showed a minimum at pH 6. The shelf life at this pH was 75 hours compared with 26.6 hours at pH 4 and 37C. Dextrose solution was found to exert a tremendous catalytic effect on the degradation of flucloxacillin

Dissolution of cholesterol in bile salt solutions: effect of a nonionic surfactant [triton X-114]

A nonionic surfactant, Triton X-114, was shown to increase the dissolution rate of cholesterol in bile salt solutions, the effect being concentration dependent. The dissolution data obtained with Triton X-114 using a series of dihydroxy and trihydroxy bile salts and those obtained with cetrimIde indicate that the accelerating effect of the nonionic surfactant may involve the formation of bile salt-nonionic surfactant systems of higher solubilizing capacity for cholesterol which enhances the dissolution process. The results obtained provide information on this class of compOunds as potential cholesterol dissolution enhancers