Histological and histochemical changes in the prostate glands of male albino rats after repeated injections of the androgenic hormone [dehydroepiandrosterone]

The effect of dehydroepi and rosterone hormone was studied in male albino rats. They were divided into four groups. Five of them were control [group 1], 10 were biopsied from the prostate gland 2 months after injections by one therapeutic dose [group 2]. Another 10 animals were biopsied after 2 months injections by double therapeutic dose [group 3] and the last 10 rats were injected by triple therapeutic dose [group 4]. Animals of group 2 showed edema of the connective tissue with shrunken acini. Animals of group 3 presented by dilated acini, congested blood vessels, thin, separated connective tissue fibers and areas of starting stratification. In group 4 there was hypertrophy, hyperplasia and metaplasia of the epithelial cells. Mitotic figures, hyperchromatic nuclei edematous connective tissue and dilated blood vessels were also noticed. Histochemically, acid phosphatase enzyme activity was increased in group 2 and showed areas of diminished activity in groups 3 and 4, while alkaline phosphatase enzyme showed increased activity in all groups. So, it was concluded that people who self administer large doses of and rogenic hormone for body build may induce abnormal histological and histochemical changes in the prostate gland

Family history of breast cancer as a risk indicator for the disease in some University Hospital

Cancer is becoming more and more prevalent in different countries all over the world. This increasing prevalence led to the rapid expansion of activities in cancer research and cancer control. Breast cancer accounts for 31.3% of all cancer among Egyptian Women [Omar, 1984]. In this work a sample of 300 patients suffering from breast cancer were chosen form National cancer institute [NCI] in Cairo and some university hospitals. A control group of 150 apparantly healthy women were chosen from the same centers but they were free from the disease. A questionnaire was fulfilled through personal interview and it included different variables relevant to the family history to breast cancer as a risk indicator. The results revealed that 6% of cancer cases had positive family history of breast cancer compared to zero% in the control group. At the same time first degree relatives with breast cancer comprised 3.4% of cases and zero% for controls. In addition it was observed that positive family history of bilateral breast affection occurred in 0.6% while family history of unilateral breast affection occured in 5.3% First degree relatives of patients with unilateral breast cancer had a higher rate 3.1% than bilateral breast cancer 0.3%. The same finding was also noted among second and far degree relative 2.2% compared to 0.3%

Study of some fatal accidents and intentional injuries in Egypt and USA [1979]

The frequencies of accidents and intentional injuries in the developing countries differ from that in the industrialized ones, consequently this comparative study was held to illustrate variation between Egypt and USA as regard the incidence and pattern of fatal accidents and interntional injuries. Data of this work were obtained from WhO records [1983] "Manual of the International Statistical Classification of Diseases. Injuries and Cause of Death, for 1979". The Egyptian figures denote that the highest rates of fatal injuries were from fire [46%] followed by motor vehicle [14.4%] and then occupational or machinery accidents [8.9%]. The pattern differ in USA as the most common fatal injuries were motor vehicle [33.8%] followed by suicide [17.6%] and homicide [14.4%]. In Egypt males are victims of accidental deaths more than females [54% and 46% respectively], while the corresponding figures in USA were 72% and 28% respectively. All ages are liable to accidents, although certain types of accidents have heavy tool in middle age persons i.e. road and machinery accidents. Deaths from violence are more common in USA than in Egypt

Tuberculosis risk factors

Tuberculosis has continued to be one of the major public health problems in many countries. Many factors are responsible for the persistance of this disease, therefore this work was directed to lay stress on these factors. The sample was taken systematically from patients attending a three agency offering services to tuberculous patients. The sample size was 200 patients while the control group comprised to 100 individuals. It was found that 77.5% of cases and 88% of controls were residing urban areas. The most frequent age among both cases and controls was from 20-39, and males were more prepondant than females. Also it was found that 65% of cases belonged to lower socioeconomic class and 20% of them were house hold contact to tuberculous patient and 30% were smoker compared to 42%, zero% and 27% in the control group respectively. Social problems were found in 22.5% of cases and in 13% in controls. Majority of patients were found to be living in poor housing conditions and 46.5% of them were below average weight, compared to 18% in control group